uncompetitive inhibitor


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uncompetitive inhibitor

a type of enzyme inhibitor in which the inhibiting compound only binds to the enzyme-substrate complex.

uncompetitive inhibitor

[un′kəmpet′itiv]
Etymology: ME, un + L, competere, to compete, inhibere, to restrain
an enzymatic inhibitor that appears to bond only to the enzyme-substrate complex and not to free enzyme molecules.

un·com·pet·i·tive in·hib·i·tor

(ŭn'kŏm-pet'i-tiv in-hib'i-tŏr)
A type of enzyme inhibitor in which the inhibiting compound only binds to the enzyme-substrate complex.
References in periodicals archive ?
One of the metabolites, urolithin A, was the most potent uncompetitive inhibitor of CYP1B1 exhibiting two fold selectivity over CYP1A1, while another, urolithin B, was a noncompetitive inhibitor with three fold selectivity.
An uncompetitive inhibitor of IMPDH inhibits by binding at the active site of the enzyme and does not compete with IMP or NAD for inhibition of the enzyme.
The first property is that an uncompetitive inhibitor as a target conjugate is preferred over a competitive inhibitor because uncompetitive inhibitors are rare in nature and should be less susceptible to interferences from drugs and naturally occurring substances, which frequently are competitive inhibitors of enzymes.
In contrast, both [gamma]-mangostin and garcinone C are uncompetitive inhibitors, while [alpha]-mangostin is a mixed-mode inhibitor of BChE.
rhynchophylla were uncompetitive inhibitors with respect to the substrate benzylamine (Fig.