uncompetitive inhibition

un·com·pet·i·tive in·hi·bi·tion

an inhibitory effect on a metabolic function, such as that of an enzyme, not based on competition for the binding site of the naturally occurring substrate but on a different effect on the molecule the function of which is being inhibited; an uncompetitive inhibition binds only to the enzyme-substrate complex.

uncompetitive inhibition

type of enzyme inhibition characterized by both increased KM and decreased Vmax.
References in periodicals archive ?
2006) reverse Pgp-mediated MDR by uncompetitive inhibition of substrate-Pgp association and inducing Pgp conformational changes.
Our data did not allow a distinction between competitive, noncompetitive, or uncompetitive inhibition because of nonlinearity in the double reciprocal and Eadie-Hofstee plots.
The objective of the present study was the development of a quantitative liquid homogeneous immunoassay specific for theophylline based on the specific uncompetitive inhibition of inosine 5'-monophosphate dehydrogenase (IMPDH) by mycophenolic acid (MPA).
Uncompetitive inhibition occurs when MPA combines with the IMPDH-XMP complex at the active site of the enzyme to form IMPDH-XMP-MPA complex, which is unable to release XMP.
Parallel slopes can be observed, indicating uncompetitive inhibition by engeletin in the manner similar to astilbin.