They demonstrated that uncoating
leading to infection occurs early in the cytoplasm, around 30 minutes after cell fusion.
a human/rhesus macaque TRIM5 isoform, which disrupts HIV from uncoating
in the cytoplasm
Coating of sperm by DEFB126 is required for the binding of sperm to oviductal epithelial cells, and the subsequent DEFB126 uncoating
is required for the capacitation of sperm.
Flavirial entry, probably at fusion and RNA uncoating
steps, was hindered by cholesterol.
A sampling of the chapter topics includes the relation between retrotransposons and their metazoan hosts, endogenous retroviruses, retroviral entry and uncoating
, reverse transcription and integration, assembly and release, retroviral restriction factors, and HTLV and HIV.
Inhibition of foot and mouth disease virus (FMDV) uncoating
by plant-derived peptide isolated from Melia azedarach L.
Another conformational change in the gp41 viral protein brings about fusion of the viral particle with the cellular membrane, which is then followed by viral uncoating
Amantadine inhibits an early step in the viral replication process, probably viral uncoating
, and also has an effect on one of the final steps of viral assembly in some strains.
They work by interfering with the uncoating
of the virus in its replication cycle, thus decreasing viral shedding.
The discovery also gives us critical insights about viral uncoating
, a little understood step in the viral lifecycle.
The monkey protein blocks the uncoating
process and stops the virus in its tracks, scientists have found.
, the viral genomic RNA is translated to produce an RNA dependent RNA polymerase in the cytoplasm.