unbound drug

Free drug Therapeutics The fraction of drug in serum that is not bound to a carrier protein or other molecule, which generally is pharmacologically active

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4 In malnourished patients with anorexia nervosa, hypoalbuminemia is common and, therefore, unbound drug concentration is higher.

Zolpidem may cause visual distortions and other psychotic symptoms

Only the unbound drug--two per cent--can be filtered, so clearance by filtration is reduced, in comparison to an unbound drug.

Metabolism and excretion: eliminating drugs from the body

Higher levels of unbound drug may exist due to hypoalbuminemia, competition for protein binding sites by uremic substances, and alterations in protein binding sites.

Medication considerations for patients with chronic kidney disease who are not yet on dialysis

Because only unbound drug is pharmacologically active, it is useful to measure the free concentration when any of the above conditions are present.

Prodrug metabolites: implications for therapeutic drug monitoring

This is important because only unbound drug molecules can exert a therapeutic effect in the body or undergo metabolism and excretion.

Breastfeeding and drugs

The common laboratory practice is to measure total phenytoin concentrations, which assumes that phenytoin protein binding is relatively constant, so that the concentration of the active unbound drug can be predicted from the total drug plasma concentration (2,3).

Evidence-based implementation of free phenytoin therapeutic drug monitoring

Disopyramide Monitor unbound drug concentrations in renal failure patients.

Standards of laboratory practice: cardiac drug monitoring

f]] are the bound and unbound drug concentrations, respectively; [[P.

Effects of uremic toxins and fatty acids on serum protein binding of furosemide: possible mechanism of the binding defect in uremia

phenytoin, which is an anti-seizure medication), there may be more unbound drugs available in infants as compared to older patients when the same dosages are given.

Pediatric medication dosing

SurModics' technology can provide a covalently bound crosslinked polymeric matrix on the surface of medical devices for use as a reservoir to incorporate unbound drugs.

Drug elution from medical device surfaces. (SurModics, Inc.: solutions in medical manufacturing)

1, 1990 CANCER RESEARCH that two LDL-bound injected drugs -- methotrexate and floxuridine -- successfully dodged the body's natural clearance mechanisms to circulate at least six times longer in the blood of rats than did unbound drugs.

The seeds of better chemotherapy?

SurModics' PhotoLink surface modification technology can provide a covalently bound crosslinked polymeric matrix on the surface of medical devices for use as a reservoir to incorporate unbound drugs.