unblinding


Also found in: Dictionary.

unblinding

A term of art used in clinical trials for the identification of the treatment code of a subject/patient or grouped results in studies where the treatment assignment was unknown to the subject and investigators.
Mentioned in ?
References in periodicals archive ?
We are therefore unblinding the study to thoroughly analyze the data, said Mike Devoy, Member of the Pharmaceuticals Division Executive Committee and Chief Medical Officer at Bayer.
Unblinding of the journal and year of publication did not occur until all of the abstracts had been evaluated against the CONSORT recommended items for abstracts.
After unblinding of the study, it was noted that most of those patients who were lost to follow-up were patients from the sequential treatment arm.
The delay between the end of a blind study and the unblinding could take several months.
However, one of the study investigators pointed out that the leadership of the trial went to extensive lengths to guard against unblinding, and that there is no evidence that unblinding of patients or investigators occurred.
5) The authors stated that early cessation of vaccination and unblinding of participants made it difficult to draw conclusions about the efficacy of the vaccine.
The systematic breaking of the blind for such cases (as required for expedited reporting to EU competent authorities) could compromise the integrity of the clinical trial: under such circumstances it may, therefore, be appropriate to reach agreement with competent authorities in advance concerning SAEs that would be considered disease related and not subject to systematic unblinding and expedited reporting.
I'm pleased with the successful unblinding of the FREEDOM-M study this quarter, as well as the very good operating results we achieved," remarked Martine Rothblatt, Ph.
Aprile says that the findings will be unveiled this fall in a dramatic protocol known as an unblinding, in which all members of the international team gather around their computers as preprogrammed software analyzes the results.
Unfortunately, observations in the operating room could not be performed without unblinding anaesthetists.
These patients crossed over and spent a median of 18 months on the aromatase inhibitor after the study's unblinding in 2005.