Though the average age of patients in our series was similar to the mean age reported by other authors in other centers in Nigeria (4-5,9) it was generally lower than the mean age seen in western clime where the majority of the patients are above 60 years of age and the incidence of perforated PUD is found to be higher in females taking ulcerogenic
Extensive review regarding the protective and therapeutic uses of curcumin by Agarwal and Goel describes both the anti-ulcer and ulcerogenic
potential of curcumin.
Tamaki, "Effect of a combination of ecabet sodium and cimetidine on experimentally induced gastric lesions and gastric mucosal resistance to ulcerogenic
agents in rats," Biological and Pharmaceutical Bulletin, vol.
Wang et al., "Peptic ulcer disease risk in chronic kidney disease: Ten-year incidence, ulcer location, and ulcerogenic
effect of medications," PLoS ONE, vol.
In addition, the analyzed extract did not induce ulcerogenic
activity, while ASA induced the formation of lesions.
Viruses are important ulcerogenic
and tumorigenic agents of the human mouth.
Mechanism of ulcerogenic
activity of indomethacin and oxyphenbutazone.
Today the use of plants as a treatment for ailments is very common.10 It is known that PapaverRhoease has been used to improve intestinal and urinary irritation and to be beneficial in respiratory diseases such as bronchitis and pneumonia.4 Also in Turkey some people use the seeds of this plant because it has anti- ulcerogenic
effects.5 In our study the young female had taken the seed of the poppy flower to treat a cough.
In this study, TAPP displayed anti-inflammatory and anti-arthritic effects without ulcerogenic
effects or analgesic activity in rats.
Evaluation of anticonceptive, anti-inflammatory and anti ulcerogenic
activities of Maytenus ilicifolia.
penicillata 400 mg/kg or indomethacin 10 mg/kg singly or in combination in half or full doses showed significant ulcerogenic
potential evidenced in raising of ulcer score by +50%, +250%, +150%, and +167% compared with normal control group, respectively (Table 4).