ugly

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A popular adjective for an aggressive disease or lesion
Infectious disease An ugly infection responds poorly to aggressive antibiotic therapy, which most commonly occurs in immunocompromised patients or those with terminal cancer
Oncology An ugly malignancy is characterised by fulminant clinical course, rapid deterioration, multiorgan failure, infection, and poor response to therapy
Pathology Ugly usually refers to a malignant lesion with bizarre, poorly differentiated cells characterised by marked nuclear atypia, pleomorphism, florid mitotic activity, and necrosis—e.g., giant cell tumour of the lung

ugly

A popular adjective for an aggressive disease or lesion Infectious disease An 'ugly' infection responds poorly to aggressive antibiotic therapy, which most commonly occurs in immunocompromised Pts or those with terminal CA Oncology An 'ugly' malignancy is characterized by fulminant deterioration, multiorgan failure, infection, poor response to therapy Surgical pathology 'Ugly' usually refers to a malignant lesion with bizarre, poorly differentiated cells characterized by marked nuclear atypia, pleomorphism and florid mitotic activity–eg, giant cell tumor of the lung. See Anaplasia.
References in classic literature ?
Like the Church, she required a noble priest at her altar; she even wanted to be married for imaginary ugliness and pretended defects, just as other women wish to be loved for the good qualities they have not, and for imaginary beauties.
I had paused half way through the hatchway, looking back, still astonished beyond measure at the grotesque ugliness of this black-faced creature.
It consists in some defect or ugliness which is not painful or destructive.
Petersburg, at the time when we reached the city, we encountered nothing but rain, bitter autumn frosts, dull skies, ugliness, and crowds of strangers who looked hostile, discontented, and disposed to take offence.
In ugliness, in so far as a man can resemble a woman.
Yet, by a strange deception, owing to the duskiness of the chamber, and the antique dresses which they still wore, the tall mirror is said to have reflected the figures of the three old, gray, withered grandsires, ridiculously contending for the skinny ugliness of a shrivelled grandam.
Immediately the moon shone out as brightly as if all the troubles of the world, and all the wickedness and the ugliness that infest human life, were past and gone forever.
They find themselves surrounded by hideous poverty, by hideous ugliness, by hideous starvation.
Sometimes such an ugliness is merely a repulsive mask.
It's full of corruption and ugliness all round, in me, too, everywhere except in your heart, which has nothing to do where I breathe.
They bothered him with their dinky deals, with their scrimping and scratching, and their sneaky attempts to hide their ugliness by the observance of one set day of sanctuary.
The man a debased specimen of one of the most primitive races of the earth, and of an ugliness which was simply devilish; the woman of high degree, beautiful, accomplished.