ugly

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A popular adjective for an aggressive disease or lesion
Infectious disease An ugly infection responds poorly to aggressive antibiotic therapy, which most commonly occurs in immunocompromised patients or those with terminal cancer
Oncology An ugly malignancy is characterised by fulminant clinical course, rapid deterioration, multiorgan failure, infection, and poor response to therapy
Pathology Ugly usually refers to a malignant lesion with bizarre, poorly differentiated cells characterised by marked nuclear atypia, pleomorphism, florid mitotic activity, and necrosis—e.g., giant cell tumour of the lung

ugly

A popular adjective for an aggressive disease or lesion Infectious disease An 'ugly' infection responds poorly to aggressive antibiotic therapy, which most commonly occurs in immunocompromised Pts or those with terminal CA Oncology An 'ugly' malignancy is characterized by fulminant deterioration, multiorgan failure, infection, poor response to therapy Surgical pathology 'Ugly' usually refers to a malignant lesion with bizarre, poorly differentiated cells characterized by marked nuclear atypia, pleomorphism and florid mitotic activity–eg, giant cell tumor of the lung. See Anaplasia.
References in periodicals archive ?
Directed by Eric "Bibo" Bergeron and Don Paul, The Road to El Dorado creates characters with the unmodeled, flat-plane features that uglify so much of digital animation.
And there's nothing that can more quickly uglify a place than billboards.
Lasser, despite pic's attempts to uglify her, has a weird elegance that somehow survives the flat-out creepiness of her character.