ugly

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A popular adjective for an aggressive disease or lesion
Infectious disease An ugly infection responds poorly to aggressive antibiotic therapy, which most commonly occurs in immunocompromised patients or those with terminal cancer
Oncology An ugly malignancy is characterised by fulminant clinical course, rapid deterioration, multiorgan failure, infection, and poor response to therapy
Pathology Ugly usually refers to a malignant lesion with bizarre, poorly differentiated cells characterised by marked nuclear atypia, pleomorphism, florid mitotic activity, and necrosis—e.g., giant cell tumour of the lung

ugly

A popular adjective for an aggressive disease or lesion Infectious disease An 'ugly' infection responds poorly to aggressive antibiotic therapy, which most commonly occurs in immunocompromised Pts or those with terminal CA Oncology An 'ugly' malignancy is characterized by fulminant deterioration, multiorgan failure, infection, poor response to therapy Surgical pathology 'Ugly' usually refers to a malignant lesion with bizarre, poorly differentiated cells characterized by marked nuclear atypia, pleomorphism and florid mitotic activity–eg, giant cell tumor of the lung. See Anaplasia.
References in classic literature ?
He grappled with the ugliest truth that he could lay his hand on, and compelled his adversary to do the same.
He said the ugliest part of it, he thought--uglier than the blood and bullet--was that the flowers were quite short, plucked close under the head.
Gandinot, the ugliest man in Roville-sur-Mer, presided over the local
The ugliest things were being said of Beaufort's dastardly manoeuvre, and his failure promised to be one of the most discreditable in the history of Wall Street.
The Damascenes are the ugliest, wickedest looking villains we have seen.
But this is the way we manage it; we collect a crowd like this one here, then each person in turn passes his head through a hole, and makes a grimace at the rest; time one who makes the ugliest, is elected pope by general acclamation; that's the way it is.
For two days he had not eaten and now he hunted in the ugliest of humors.
On such rare afternoons the ugliest of cities becomes the most poetic, and months of sodden days are offset by a moment of miracle.
It was the chilliest, ugliest, emptiest, gloomiest place I ever entered in my life; the idea of doing anything but sitting down and crying in it seemed to me quite preposterous; but the committee took a different view of the matter, and praised the Lecture Theater as a perfect ballroom.
That is what I want you to do, and when you have filled this out we will go on enlarging it till your waist is more like that of Hebe, goddess of health, and less like that of a fashion-plate the ugliest thing imaginable.
They were looking across the Isle of Purbeck and on to Swanage, soon to be the most important town of all, and ugliest of the three.
They nurse and cuddle their presentiments, and make darlings of their ugliest thoughts, as they do of their deformed children.