ugly

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A popular adjective for an aggressive disease or lesion
Infectious disease An ugly infection responds poorly to aggressive antibiotic therapy, which most commonly occurs in immunocompromised patients or those with terminal cancer
Oncology An ugly malignancy is characterised by fulminant clinical course, rapid deterioration, multiorgan failure, infection, and poor response to therapy
Pathology Ugly usually refers to a malignant lesion with bizarre, poorly differentiated cells characterised by marked nuclear atypia, pleomorphism, florid mitotic activity, and necrosis—e.g., giant cell tumour of the lung

ugly

A popular adjective for an aggressive disease or lesion Infectious disease An 'ugly' infection responds poorly to aggressive antibiotic therapy, which most commonly occurs in immunocompromised Pts or those with terminal CA Oncology An 'ugly' malignancy is characterized by fulminant deterioration, multiorgan failure, infection, poor response to therapy Surgical pathology 'Ugly' usually refers to a malignant lesion with bizarre, poorly differentiated cells characterized by marked nuclear atypia, pleomorphism and florid mitotic activity–eg, giant cell tumor of the lung. See Anaplasia.
References in periodicals archive ?
com/worlds-ugliest-dog-2015-quasi-modo-deformed-pit-bull-dutch-shepherd-mix-wins-years-1986725) World's Ugliest Dog 2015
BEAUTY IN THE EYE OF THE | |BEHOLDER: Mugly, voted the World's Ugliest Dog in 2012
Coun Henley added: "Having seen the Tesco in Woolwich win the award for Britain's ugliest building, I would say this is a shoo-in for next year.
Mr Sobel declared: "Peanut is one of the ugliest dogs we have ever judged.
I will no longer be calling it the ugliest damn building in America," he said in a following tweet.
But despite it being the ugliest creature on earth at least it's name isn't the worst.
Large, flightless, nocturnal and endangered, New Zealand's native kakapo was voted the world's second ugliest animal and dubbed a "rubbish parrot" by Ugly Animal Preservation Society, Stuff.
MIKE HUNTER, Guisborough SO Redcar Vertical Pier (giant helter skelter) has been voted one of the ugliest buildings in the UK.
Boyle and his partners snapped up Cumbernauld shopping centre, once voted the UK's ugliest building, after it was put on the market for PS3.
An old communist TV tower in Prague, which was voted the world's second ugliest building, has been transformed into a five-star one-room hotel.
MUGLY, the world's ugliest dog, was in Cardiff yesterday to launch a new designer pet boutique and spa.
The Ugly Sweater Run, dubbed "the ugliest 5K on the planet," offers an “ugly”-saturated, fun-filled experience for runners and walkers of all ages across city streets this winter.