ugly

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A popular adjective for an aggressive disease or lesion
Infectious disease An ugly infection responds poorly to aggressive antibiotic therapy, which most commonly occurs in immunocompromised patients or those with terminal cancer
Oncology An ugly malignancy is characterised by fulminant clinical course, rapid deterioration, multiorgan failure, infection, and poor response to therapy
Pathology Ugly usually refers to a malignant lesion with bizarre, poorly differentiated cells characterised by marked nuclear atypia, pleomorphism, florid mitotic activity, and necrosis—e.g., giant cell tumour of the lung

ugly

A popular adjective for an aggressive disease or lesion Infectious disease An 'ugly' infection responds poorly to aggressive antibiotic therapy, which most commonly occurs in immunocompromised Pts or those with terminal CA Oncology An 'ugly' malignancy is characterized by fulminant deterioration, multiorgan failure, infection, poor response to therapy Surgical pathology 'Ugly' usually refers to a malignant lesion with bizarre, poorly differentiated cells characterized by marked nuclear atypia, pleomorphism and florid mitotic activity–eg, giant cell tumor of the lung. See Anaplasia.
References in periodicals archive ?
At first, Tally is repelled by the community of escaped Uglies, and is appalled that people would allow themselves to be less than beautiful and to show their age.
MINNEAPOLIS -- Minneapolis game studio Bumpin' Uglies LLC is in alpha on Bumpin' Uglies, which could shape up to be a breakout mobile hit when released later this year.
UGLIES Launches The Great American Underwear Exchange