ubiquitin-proteasome system

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Related to ubiquitin-proteasome system: Ubiquitin proteasome pathway, Immunoproteasome, E3 Ubiquitin Ligase

ubiquitin-proteasome system (UPS),

a multicomponent system that identifies and degrades unwanted proteins in the cytoplasm of all cells; involved in cell growth and differentiation, DNA replication and repair, apoptosis, and stress and immune responses.
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In addition to ubiquitin-proteasome system, other proteins can regulate Nrf2 by interacting with the Nrf2-Keap1 complex.
The ubiquitin-proteasome system in HIV replication: Potential targets for antiretroviral therapy.
The regulated modification and degradation of cellular proteins by the ubiquitin-proteasome system are critical for modulation of many essential cellular processes including cell death.
We investigated the effects that the compound may have on the ocular levels of (i) inflammatory markers such as the ocular ubiquitin-proteasome system and NF-[kappa]B pathway; (ii) prooxidant and antioxidant markers such as nitrotyrosine, MnSOD, and GPX; (iii) proapoptotic/antiapoptotic factors caspases and Bcl-xl protein; (iv) markers of endothelial progenitor cells (EPCs) recruitment such as CD34 and CD117.
Chandu, "The ubiquitin-proteasome system," Journal of Biosciences, vol.
Ubiquitin-Proteasome System. Ubiquitin-proteasome system (UPS), the major mechanism of proteolysis, is activated in skeletal muscle in CKD patients, as well as in patients with other chronic diseases.
Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions.
This article focuses on three major proteolytic systems known to be affected by alcohol consumption--the lysosome, the ubiquitin-proteasome system, and the calpains.
The degradation of irreversibly damaged protein is most often mediated by the ubiquitin-proteasome system (UPS) [178-180].
The ubiquitin-proteasome system (UPS) is part of the physiological unfolded protein response, which ameliorates endoplasmic reticulum (ER) stress [9].

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