USP15(redirected from ubiquitin thiolesterase 15)
USP15A gene on chromosome 12q14 that encodes an enzyme which deubiquitinates Lys-48-linked polyubiquitinated proteins, targeting them against proteasomal degradation. USP15 protects APC and HPV type-16 protein E6 against degradation via the ubiquitin proteasome pathway. It is expressed in skeletal muscle, kidneys, heart, placenta, liver, thymus, lungs and ovaries.
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