UCHL1

(redirected from ubiquitin carboxyl-terminal esterase L1)

UCHL1

A gene on chromosome 4p14 that encodes a ubiquitin-protein hydrolase, involved both in processing of ubiquitin precursors and ubiquitinated proteins, which recognises and hydrolyses a peptide bond at the C-terminal glycine of ubiquitin. UCHL1 also binds free monoubiquitin and may prevent its degradation in lysosomes.
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As shown in Figure 3, laminin-derived signaling induced no significant transcriptional down-regulation of octamer-binding transcription factor 4 (OCT4), homeobox transcription factor nanog (NANOG), epithelial cellular adhesion molecule (EPCAM), THY-1 T-cell antigen (THY1), or ubiquitin carboxyl-terminal esterase L1 (UCHL1) throughout the entire culture period.
In the current study, we chose to examine the expression of ubiquitin carboxyl-terminal esterase L1 (UCHL1); also known as protein gene product 9.5, because it is expressed in spermatogonia of many species including bovine (2), pigs (12), mice (13), monkeys (14), etc.
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