ubiquitin


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u·biq·ui·tin

(ū-bik'kwi-tin), [MIM*191320]
A small (76 amino acyl residues) protein found in all cells of higher organisms and one with a structure that has changed minimally during evolutionary history; involved in at least two processes; histone modification and intracellular protein breakdown.

ubiquitin

(yo͞o-bĭk′wĭ-tĭn)
n.
A small protein found in all eukaryotic cells that attaches to other proteins, thereby regulating their activity or location or marking them for degradation.

u·bi·qui·tin

(yū-bik'kwi-tin)
A small protein found in all cells of higher organisms; its structure has changed minimally during evolutionary history; involved in histone modification and intracellular protein breakdown.

ubiquitin

A small 76-residue protein found in all animal cells and known to have altered minimally throughout evolutionary history. Ubiquitin is linked by covalent bonds to proteins destined for destruction by PROTEASOMES.

ubiquitin

a small PROTEIN, present in all eukaryotic cells (ubiquitous protein), containing a highly conserved sequence of 76 AMINO ACIDS, that is identical in a wide range of organisms including humans, fish and insects. Ubiquitin is involved in a number of cellular functions, such as protein degradation and modifications to CHROMATIN structure.
References in periodicals archive ?
The UBL domain of human DDI2 is involved in Nrf1 processing, (53) probably through interaction with ubiquitin chains.
Valverde et al., "Selectivity of the ubiquitin pathway for oxidatively modified proteins: relevance to protein precipitation diseases," FASEB Journal, vol.
Ubiquitin C-Terminal Hydrolase (UCH) and Bone Formation.
Springer, "Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin," PLoS Computational Biology, vol.
In addition to UBE3A, it was revealed that there was association between synaptic pathology in autism and other ubiquitin genes, including SHANKS, RFWD2, FBXO40, and PARK2 (32,33).
'We are also working on an engineered ubiquitin that targets a corn virus responsible for destroying large swathes of corn fields in North America,' Zhang said.
Both, HAK48 and K63 ubiquitin have all internal lysine residues of ubiquitin mutated to arginine except K48 or K63, allowing polyubiquitination to only occur on those lysine residues.
Blocking of Pin1 Activity Increases the Modification of Ubiquitin in PSD Proteins.
PDLIM2 functions as E3 ubiquitin ligase through its LIM domain and facilitates the polyubiquitination of p65/RelA.
Davies, "Ubiquitin conjugation is not required for the degradation of oxidized proteins by proteasome," The Journal of Biological Chemistry, vol.
USP8, also designated as Ub-specific protease Y, is an ubiquitin isopeptidase that belongs to the USP family of cysteine proteases.