The UBL domain of human DDI2 is involved in Nrf1 processing, (53) probably through interaction with ubiquitin
Valverde et al., "Selectivity of the ubiquitin
pathway for oxidatively modified proteins: relevance to protein precipitation diseases," FASEB Journal, vol.
C-Terminal Hydrolase (UCH) and Bone Formation.
Springer, "Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin
Ligase Parkin," PLoS Computational Biology, vol.
In addition to UBE3A, it was revealed that there was association between synaptic pathology in autism and other ubiquitin
genes, including SHANKS, RFWD2, FBXO40, and PARK2 (32,33).
'We are also working on an engineered ubiquitin
that targets a corn virus responsible for destroying large swathes of corn fields in North America,' Zhang said.
Both, HAK48 and K63 ubiquitin
have all internal lysine residues of ubiquitin
mutated to arginine except K48 or K63, allowing polyubiquitination to only occur on those lysine residues.
Blocking of Pin1 Activity Increases the Modification of Ubiquitin
in PSD Proteins.
The HA-tagged ubiquitin
plasmid was purchased from Addgene (Cambridge, MA).
PDLIM2 functions as E3 ubiquitin
ligase through its LIM domain and facilitates the polyubiquitination of p65/RelA.
conjugation is not required for the degradation of oxidized proteins by proteasome," The Journal of Biological Chemistry, vol.
USP8, also designated as Ub-specific protease Y, is an ubiquitin
isopeptidase that belongs to the USP family of cysteine proteases.