ubiquitin


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u·biq·ui·tin

(ū-bik'kwi-tin), [MIM*191320]
A small (76 amino acyl residues) protein found in all cells of higher organisms and one with a structure that has changed minimally during evolutionary history; involved in at least two processes; histone modification and intracellular protein breakdown.

ubiquitin

(yo͞o-bĭk′wĭ-tĭn)
n.
A small protein found in all eukaryotic cells that attaches to other proteins, thereby regulating their activity or location or marking them for degradation.

ubiquitin

[yo̅o̅bik′witin]
a small polypeptide that is involved in histone modification and is a marker for intracellular protein transport and breakdown. It is found in all cells of higher organisms.

u·bi·qui·tin

(yū-bik'kwi-tin)
A small protein found in all cells of higher organisms; its structure has changed minimally during evolutionary history; involved in histone modification and intracellular protein breakdown.

ubiquitin

A small 76-residue protein found in all animal cells and known to have altered minimally throughout evolutionary history. Ubiquitin is linked by covalent bonds to proteins destined for destruction by PROTEASOMES.

ubiquitin

a small PROTEIN, present in all eukaryotic cells (ubiquitous protein), containing a highly conserved sequence of 76 AMINO ACIDS, that is identical in a wide range of organisms including humans, fish and insects. Ubiquitin is involved in a number of cellular functions, such as protein degradation and modifications to CHROMATIN structure.

ubiquitin (yōōˈ·biˑ·kwi·tin),

n a 76-amino acid polypeptide from modification of histones; present in yeast and in most eukaryotic cells.

ubiquitin

heat shock (cell stress) protein present in mammalian cytosol; attaches to other cytosolic proteins and marks them for degradation either by specific proteases or by lysosomal enzymes.
References in periodicals archive ?
If FUS staining is negative, the diagnosis is FTLD involving the ubiquitin proteasome system (FTLD-UPS), and more specifically, it may be associated with mutations in the CHMP2Ba gene (FTD-3) or possibly a FUS-negative sporadic FTLD-UPS.
To validate the differential excretion of m/z 6188 ubiquitin in the urine of DM-NP patients compared with the other groups, we performed Western blotting on pooled samples from each group.
Fernandez, however, observed that the trace of how hard the folding ubiquitin molecule pulled on the microscope tip was different each time that he ran the experiment.
Similarly, UBE3A, which is another important molecule in the ubiquitin system, was found to be associated with autistic symptoms in the Angelman syndrome (25,26).
5 [micro]M biotinylated or non-tagged ubiquitin, 100 nM His-tagged El, approximately 1-2.
The researchers said they also created ubiquitin variant (UbVs) that blocks the Crimean-Congo virus, the cause of a haemorrhagic fever that kills about 40 per cent of those infected, Medical Xpress reported.
The team also found that BRCA1 relies on a partner protein, BARD1, to perform its ubiquitin attachment role.
Li MV, Zhu M, Zhu B, Wang ZQ: Cholera toxin suppresses expression of ubiquitin editing enzyme A20 and enhances transcytosis.
Ubiquitinylation is a reversible posttranslational modification, and a family of proteases, the deubiquitinylating enzymes (DUBs), can remove ubiquitin from substrates, thereby regulating the ubiquitinylation process and recycling ubiquitin.
Ubiquitin clinging to a protein is one signal that the protein is ready for the garbage.
These ubiquitin pathways evolved much in parallel to other familiar markup systems used in the cell, namely methylation of DNA, and phosphorylation of specific amino acids in proteins.
Patsi will oversee the current portfolio in EMEA as well as international efforts for the company's pipeline of clinical programs in areas including immunotherapy, epigenetics, ubiquitin ligase targets, cancer metabolism and others.