ubiquinone

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Related to ubiquinones: Coq10

coenzyme

[ko-en´zīm]

an organic molecule, usually containing phosphorus and some vitamins, sometimes separable from the enzyme protein; a coenzyme and an apoenzyme must unite in order to function (as a holoenzyme).

coenzyme A a coenzyme essential for carbohydrate and fat metabolism; among its constituents are pantothenic acid and a terminal SH group, which forms linkages with various acids, e.g., acetic acid (acetyl CoA) and fatty acids (acyl CoA); abbreviated CoA.

coenzyme Q any of a group of related quinones occurring in the lipid fraction of mitochondria and serving, along with the cytochromes, as an intermediate in electron transport; they are similar in structure and function to vitamin K₁.

u·bi·qui·none

(ū'bi-kwī'nōn, ū-bik'wi-nōn),

A 2,3-dimethoxy-5-methyl-1,4-benzoquinone with a multiprenyl side chain; a mobile component of electron transport.
See also: coenzyme Q.

ubiquinone

(yo͞o′bĭ-kwĭ-nōn′, -kwĭn′ōn′)

A quinone compound that serves as an electron carrier between flavoproteins and in cellular respiration.

coenzyme Q10

A factor present in mitochondria which extracts energy from foods. It has acquired a reputation among fringe nutritionists as being effective in detoxifying patients with an overdose of environmental pollutants; it is also claimed to be beneficial in treating hypertension, obesity, periodontal disease, preventing cancer, increasing longevity and revitalising the immune system.

u·bi·qui·none

(yū'bi-kwi'nōn)

A 2,3-dimethoxy-5-methyl-1,4-benzoquinone with a multiprenyl side chain; a mobile component of electron transport.
See also: coenzyme Q

ubiquinone

coenzyme Q

a type of QUINONE that can be reversibly reduced. It functions as an electron carrier in ELECTRON TRANSPORT SYSTEMS.

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References in periodicals archive ?

Isoprenoid includes cholesterol, bile acids, steroid hormones, dolichol, ubiquinone, prenylated proteins, and a wide variety of plant terpenoids [1].

In P falciparum, the biosynthesis of ubiquinone or coenzyme Q involves two major steps: synthesis of the benzoquinone by the shikimate pathway and synthesis of the isoprene side chain by the MEP pathway.

Exploring drug targets in isoprenoid biosynthetic pathway for Plasmodium falciparum

Since antioxidants act not individually, but synergistically, a mixture of vitamin E, ubiquinone [Q.sub.9], and [beta]-carotene was added to the animal diet.

A diet enriched with [beta]-carotene (2 mg/kg body weight), [alpha]-tocopherol (2 mg/kg body weight), and ubiquinone [Q.sub.9] (8 mg/kg body weight) was administered daily for 15 days prior to LPS treatment.

Anti-inflammatory effects of IKK inhibitor XII, thymulin, and fat-soluble antioxidants in LPS-treated mice

The kinetics of the redox reactions of ubiquinone related to the electron-transport activity in the respiratory chain.

Branch-point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteins.

Mitochondrial coenzyme Q10 determination by isotope-dilution liquid chromatography-tandem mass spectrometry

Whether this represents occupation of an inhibitory binding site similar to group II ubiquinones or interference in cyclophylin D binding to the pore is unknown.

Quinones and aromatic chemical compounds in particulate matter induce mitochondrial dysfunction: implications for ultrafine particle toxicity

Laaksonen, "Molecular dynamics simulations of ubiquinone; a survey over torsional potentials and hydrogen bonds," Molecular Physics, vol.

Impact of Antioxidants on Cardiolipin Oxidation in Liposomes: Why Mitochondrial Cardiolipin Serves as an Apoptotic Signal?

Coenzyme [Q.sub.10] (Co[Q.sub.10]), the predominant ubiquinone species in humans, functions as an electron carrier in the mitochondrial electron transport chain (ETC) and as an intracellular antioxidant (1).

Determination of coenzyme [Q.sub.10] status in blood mononuclear cells, skeletal muscle, and plasma by HPLC with di-propoxy-coenzyme [Q.sub.10] as an internal standard

Reference Baseline values values TBARS < 4.50 4.380 [+ or -] 0.153 [gamma]-Tocopherol 2.00-700 1.625 [+ or -] 0.160 [alpha]-Tocopherol 15-40 17.98 [+ or -] 0.920 [beta]-Carotene 0.30-3.00 0.983 [+ or -] 0.164 Co[Q.sub.10-TOTAL] 0.40-1.00 0.512 [+ or -] 0.164 Ubiquinol (3 months) TBARS 4.200 [+ or -] 0.241 [gamma]-Tocopherol 1.927 [+ or -] 0.304 [alpha]-Tocopherol 19.14 [+ or -] 0.872 [beta]-Carotene 0.804 [+ or -] 0.129 Co[Q.sub.10-TOTAL] 3.016 [+ or -] 0.307 * [micro]mol-L: micromol-liter; TBARS: thiobarbituric acids reactive substances; [gamma]-tocopherol: gamma-tocopherol; [alpha]-tocopherol: alpha-tocopherol; Co[Q.sub.10total] (ubiquinol + ubiquinone); data are expressed as mean [+ or -] standard error of the mean; * P < 0.0001.

Ubiquinol improves symptoms in children with autism

Plasma ubiquinone to ubiquinol ratio in patients with hepatitis, cirrhosis, and hepatoma, and in patients treated with percutaneous transluminal coronary repertusion.

HPLC analysis of reduced and oxidized coenzyme [Q.sub.10] in human plasma

Previous reports of the activity of complex I have varied according to the enzyme preparations and the ubiquinone species used.