ubiquinone

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Related to ubiquinones: Coq10

coenzyme

[ko-en´zīm]

an organic molecule, usually containing phosphorus and some vitamins, sometimes separable from the enzyme protein; a coenzyme and an apoenzyme must unite in order to function (as a holoenzyme).

coenzyme A a coenzyme essential for carbohydrate and fat metabolism; among its constituents are pantothenic acid and a terminal SH group, which forms linkages with various acids, e.g., acetic acid (acetyl CoA) and fatty acids (acyl CoA); abbreviated CoA.

coenzyme Q any of a group of related quinones occurring in the lipid fraction of mitochondria and serving, along with the cytochromes, as an intermediate in electron transport; they are similar in structure and function to vitamin K₁.

u·bi·qui·none

(ū'bi-kwī'nōn, ū-bik'wi-nōn),

A 2,3-dimethoxy-5-methyl-1,4-benzoquinone with a multiprenyl side chain; a mobile component of electron transport.
See also: coenzyme Q.

ubiquinone

/ubi·qui·none/ (Q) (Q10) (u″bĭ-kwĭ-nōn´) a quinone derivative with an unsaturated branched hydrocarbon side chain occurring in the lipid core of inner mitochondrial membranes and functioning in the electron transport chain. In naturopathic practice it is used for a wide variety of indications; also used as a dietary supplement for its antioxidant properties.

ubiquinone

(yo͞o′bĭ-kwĭ-nōn′, -kwĭn′ōn′)

A quinone compound that serves as an electron carrier between flavoproteins and in cellular respiration.

ubiquinone

[yo̅o̅bik′winōn]

a naturally occurring organic compound found in the lipid core of mitochondrial membranes. It functions as a carrier in the electron transport chain that produces energy. Formerly called coenzyme Q. 2. an herbal supplement used in the treatment of cardiac as well as several other chronic and hereditary diseases. The safety and/or effectiveness of this supplement has not been established by the FDA.

coenzyme Q10

A factor present in mitochondria which extracts energy from foods. It has acquired a reputation among fringe nutritionists as being effective in detoxifying patients with an overdose of environmental pollutants; it is also claimed to be beneficial in treating hypertension, obesity, periodontal disease, preventing cancer, increasing longevity and revitalising the immune system.

u·bi·qui·none

(yū'bi-kwi'nōn)

A 2,3-dimethoxy-5-methyl-1,4-benzoquinone with a multiprenyl side chain; a mobile component of electron transport.
See also: coenzyme Q

ubiquinone

coenzyme Q

a type of QUINONE that can be reversibly reduced. It functions as an electron carrier in ELECTRON TRANSPORT SYSTEMS.

ubiquinone

coenzyme Q; component of the electrontransfer chain of oxidative phosphorylation.

References in periodicals archive ?

Branch-point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteins.

Evaluation of ubiquinone concentration and mitochondrial function relative to cerivastatin-induced skeletal myopathy in rats.

Simultaneous determination of ubiquinol and ubiquinone in skeletal muscle of pediatric patients.

Mitochondrial coenzyme Q10 determination by isotope-dilution liquid chromatography-tandem mass spectrometry

Whether this represents occupation of an inhibitory binding site similar to group II ubiquinones or interference in cyclophylin D binding to the pore is unknown.

One possibility is binding to the putative ubiquinone binding site mentioned above.

Quinones and aromatic chemical compounds in particulate matter induce mitochondrial dysfunction: implications for ultrafine particle toxicity

Murphy, "Reactivity of ubiquinone and ubiquinol with superoxide and the hydroperoxyl radical: implications for in vivo antioxidant activity," Free Radical Biology and Medicine, vol.

Impact of Antioxidants on Cardiolipin Oxidation in Liposomes: Why Mitochondrial Cardiolipin Serves as an Apoptotic Signal?

Biochemical, physiological and medical aspects of ubiquinone function.

Determination of coenzyme [Q.sub.10] status in blood mononuclear cells, skeletal muscle, and plasma by HPLC with di-propoxy-coenzyme [Q.sub.10] as an internal standard

Plasma ubiquinone to ubiquinol ratio in patients with hepatitis, cirrhosis, and hepatoma, and in patients treated with percutaneous transluminal coronary repertusion.

Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress.

HPLC analysis of reduced and oxidized coenzyme [Q.sub.10] in human plasma

One of the main functions of complex I is the transport of electrons across the inner mitochondrial membrane via the oxidation of NADH coupled to reduction of ubiquinone (2).