M2 PHARMA-January 19, 2018-Eiger BioPharmaceuticals to Discontinue Development of Ubenimex in PAH
No safety signals attributed to ubenimex were identified in the preliminary analysis.
Eiger will continue to develop ubenimex for lymphedema based on its distinct mechanism of action impacting lymphangiogenesis as published in Science Translational Medicine (Tian et al, May 2017).
Abe, "Induction of apoptosis by bestatin (ubenimex
) in human leukemic cell lines," Leukemia, vol.
The inhibition of CD 13 by the commercially available neutralizing antibody ubenimex resulted in the increase of ROS in response to chemotherapy, leading to the significant reduction in the size of tumours in subcutaneous mouse xenograft models (Fig.
(2016) A CD13 inhibitor, ubenimex, synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma.
The inhibition of CD13 by the commercially available neutralizing antibody ubenimex results in the increase of ROS, leading to apoptosis.
M2 EQUITYBITES-July 20, 2016-Eiger BioPharmaceuticals doses first patient in Phase 2 LIBERTY study of Ubenimex
Eiger BioPharmaceuticals, a clinical-stage biopharmaceutical company, has dosed the first patient in the Phase 2 LIBERTY study of Ubenimex in Pulmonary Arterial Hypertension, it was reported yesterday.
The study will assess the effects of Ubenimex added to current standard of care in patients with pulmonary arterial hypertension.
Piper Jaffray analyst Edward Tenthoff cut his price target for Eiger BioPharmaceuticals to $17 from $35 after the Phase II Liberty study of ubenimex
in pulmonary arterial hypertension failed to meet the primary and secondary endpoints.
M2 PHARMA-July 20, 2016-Eiger BioPharmaceuticals doses first patient in Phase 2 LIBERTY study of Ubenimex