tyrosinase


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Related to tyrosinase: tyrosine

mon·o·phe·nol mon·o·ox·y·gen·ase

(mon-ō-fē'nol mon'ō-oksĭ-jen-ās'),
1. A copper-containing oxidoreductase that catalyzes the oxidation of o-diphenols to o-quinones by O2, with the incorporation of one of the two oxygen atoms in the product; it also catalyzes the oxidation of monophenols, such as l-tyrosine, to dihydroxy-l-phenylalanine (dopa), a precursor of melanin and epinephrine (catecholamines), and can act as a catechol oxidase; a deficiency of this enzyme is observed in several forms of albinism. Synonym(s): cresolase, monophenol oxidase, tyrosinase
2. Synonym(s): laccase

tyrosinase

(tī-rŏs′ə-nās′, -nāz′)
n.
A copper-containing enzyme of plant and animal tissues that catalyzes the production of melanin and other pigments from tyrosine by oxidation, as in the blackening of a peeled or sliced potato exposed to air.

tyrosinase

(1) Catechol oxidase, EC 1.10.3.1. 
(2) Monophenol monooxygenase, EC 1.14.18.1.

tyrosinase

A copper-containing enzyme that occurs in melanocytes and catalyses the production of MELANIN from TYROSINE. Also known as monophenol mono-oxygenase.

Tyrosinase

An enzyme in a pigment cell which helps change tyrosine to DOPA during the process of making melanin.
Mentioned in: Albinism

tyrosinase

an enzyme important in the production of melanin from tyrosine. Deficiency has been reported in Chow Chows where it is transient and is associated with hypopigmentation of the oral mucosa and hair.
References in periodicals archive ?
Tyrosinase enzyme is a metal-enzyme containing two atoms of copper, but it was found that (-)-epicatechin doesn't bind directly to these atoms but has a hydroxyl group directed toward one Cu atom, in a similar way of tropolone.
The extracts from these trees are shown to stop tyrosinase activity like HQ.
The OCA2 protein also participates in the localization of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1) to the plasma membrane and thus involved in biogenesis of melanosomes.
Studies suggested that it regulates the melanogenesis through binding to a highly conserved M-box (GTCATGTGCT) and E-box (TCATGTG) motif upstream of the tyrosinase promoter, which strongly stimulates the tyrosinase promoter activities and promotes tyrosinase expression (Yasumoto et al.
It acts as a tyrosinase inhibitor and takes several months to show an effect.
CoValence says that in addition to brightening, the actives inhibit tyrosinase activity, prevent damage caused by the environment and protect nuclear and mitochondria DNA.
A concentrated mixture of mucus, tyrosinase, lysine and sodium chloride," explained a colleague.
The scientists isolated two chemicals from the plant that have the ability to block tyrosinase, an enzyme that controls the synthesis of melanin, a dark pigment responsible for colouring skin, hair, and eyes.
Epionce also offers a non-hydroquinone skin-whitening and -bleaching product (Melanolyte), incorporating various natural ingredients proven to block the tyrosinase enzyme.
The investigators used microdermabrasion to improve penetration to the target site, followed by an effective tyrosinase inhibitor to suppress melanocytes and remove melanin from the stratum corneum, she explained, adding that sunscreens and topical vitamin C were also used.