matrix metalloproteinase 2

(redirected from type IV collagenase)

matrix metalloproteinase 2

A 62-kD tissue enzyme encoded on chromosome 16q13-q21 that degrades collagens and other matrix proteins, and which may be linked to cancer.

Cytokine inducers
Activin, CD40L, EGF, endothelin-1, FGF-b, FGF-3, G-CSF, GM-CSF, HGF, IFN-α, IFN-γ, IGF-1, IL-1α, IL-1β, IL-3, IL-6, sIL-6 Rα, IL-8, IL-18, LIF, M-CSF, MIF, oncostatin M, PDGF, SCF, TGF-α, TGF-β1, TNF-α, VEGF.
 
Substrates
3 α-chains of native Collagens I, IV, V, VII, X, XI, and XIV; gelatin, elastin, fibronectin, laminin-1, laminin-5, galectin, aggrecan, decorin, hyaluronidase-treated versican, proteoglycan link protein, osteonectin, MBP, GST-TNF/TNF peptide, IL-1β, serum amyloid A, APP695, α1-AT, prolysyl oxidase fusion protein, IGF-BP5, IGF-BP5, FGF R1, MMP-1, MMP-9, MMP-13.
References in periodicals archive ?
Within the MMP family, gelatinases A (72 kDa gelatinase, type IV collagenase, MMP-2) and B (92 kDa gelatinase, type IV collagenase, MMP-9) play critical roles in ECM degradation and cell migration leading to tumor cell invasion in breast cancer (Egeblad and Werb 2002).
Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion.
Determination of stromelysin-1, 72 and 92 kDa type IV collagenase, tissue inhibitor of metalloproteinase-1 (TIMP-1), and TIMP-2 in synovial fluid and serum from patients with rheumatoid arthritis.
Immunohistochemically distribution of type IV collagenase in normal, benign and malignant breast tissue.
Type IV collagenase immunoreactivity in invasive breast carcinoma.
72 kD and 92 kD type IV collagenase, type IV collagen and laminin mRNAs in breast cancer: a study by in situ hybridization.
SV40-transformed human lung fibroblasts secrete a 92 kDa type IV collagenase which is identical to that secreted by normal human macrophages.
M(r) 92,000 type IV collagenase is increased in plasma of patients with colon cancer and breast cancer.