type IV collagen


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type IV col·la·gen

a less distinctly fibrillar form of collagen characteristic of the lamina densa of the basal lamina.
References in periodicals archive ?
Type IV collagen induces down-regulation of steroidogenic response to gonadotropins in adult rat Leydig cells involving mitogen-activated protein kinase.
Different properties of glioma cell proliferation and clearance are associated with distinct glioma ECM components; in 20-day gliomas, ECM components such as chondroitin sulfate proteoglycan, tenascin C, and type IV collagen were elevated, in comparison with values obtained for the 10-day glioma group.
AS is an inherited disorder affecting alpha chains of type IV collagen. There are multiple mutations and modes of inheritance possible including X linked, autosomal recessive, and autosomal dominant [1].
The test was realized using the following method: Sodium hydrogen carbonate solution (60 uL, pH 12) was added to 0.3% type IV collagen (0.9 mL) and adjusted to pH 8.
Type IV collagen, a network-forming n type,14 and laminins are the most abundant building blocks of the basement membrane.14-17 Collagen can take part in signal transduction via transmembrane receptors, such as integrins.16,18 Moreover, it was shown that the non-collagenous (NC1) domain of collagen takes part in the regulation of adhesion, proliferation and apoptosis in various cell types via their interactions with integrins, such as a6b1.
Characterization of hydra type IV collagen. Type IV collagen is essential for head regeneration and its expression is up-regulated upon exposure to glucose.
Recently, we reported that type IV collagen is a target of miR135b and that miR135b suppression may improve the microenvironment and also increase the proliferative potential of epidermal basal cells [12].
(12.) Zhu D, Kim Y, Steffes MW, et al.: Glomerular distribution of type IV collagen in diabetes by high resolution quantitative immunochemistry.
The MMP 1 in the human body and MMP 13 in rats are the degrading enzymes of type I and III interstitial collagens; the natural substrates of MMP 2 are the components of type IV collagen (gelatin) molecules and other ECM.5,10 TIMPs are regulators of MMPs expression, of which TIMP 1 is an inhibitor of MMP1 and MMP 13.
Decreased interaction of fibronectin, type IV collagen, and heparin due to nonenzymatic glycation.
The cells were initially grown on type IV collagen and in two-dimensional growth conditions there were no signs of kidney structure development.