great alveolar cells

(redirected from type II pneumocyte)

great al·ve·o·lar cells

cuboidal cells connected with the squamous pulmonary alveolar cells and having in their cytoplasm lamellated bodies (cytosomes) that represent the source of the surfactant that coats the alveoli.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
Long term culture of the a549 cancer cell line promotes multilamellar body formation and differentiation towards an alveolar type ii pneumocyte phenotype.
The characteristic histopathological pattern of IPF includes type II pneumocyte hyperplasia and abnormal mesenchymal cell proliferation.
Lamellar bodies are secreted by the type II pneumocyte and unfold to form tubular myelin and other large aggregates that are absorbed onto the hydrated inner layer of the alveoli.
Histologic analysis showed that lesions were similar to those observed in humans and indicated necrotizing bronchointerstitial pneumonia with type II pneumocyte hyperplasia, abundant fibrin, and streaming mucus in airways.
In contrast, lungs involved with diffuse alveolar damage exhibit widened alveolar septa, reduced numbers of aerated airspaces, and other histologic changes of injury, including the presence of hyaline membranes lying within airspaces, and type II pneumocyte hyperplasia (Figure 1, C through E).
Alveolar walls were thickened and showed necrosis of lining epithelium and type II pneumocyte hyperplasia.
The renewal strategy of alveolar epithelium is different from that operating in conducting airways, with the type II pneumocyte exerting both specialized (eg, the production of surfactant proteins) and precursor functions.
Cellular debris, including degenerating alveolar macrophages, sloughed pneumocytes, and cholesterol clefts, is often present, and there may be a regenerative type II pneumocyte hyperplasia.
The shape and location of the antigen-positive cells indicated that they were type II pneumocytes. To confirm this, we used surfactant as a marker of type II pneumocyte (18).
There is evidence that sclerosing hemangioma of the lung shows evidence of type II pneumocyte differentiation (Figure):
In summary, we believe that the uniform and strong positivity for TTF-1 in both pale cells and cuboidal cells supports the notion that this neoplasm shows evidence of type II pneumocyte differentiation.