DIO2

(redirected from type II iodothyronine deiodinase)

DIO2

A gene on chromosome 14q24.2-q24.3 that encodes a protein of the iodothyronine deiodinase family which activates thyroid hormone, converting prohormone thyroxine (T4) by outer-ring deiodination to bioactive 3,3’,5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas.
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Type II iodothyronine deiodinase (D2) is encoded by the gene DIO2 whose major function is to enzymatically convert thyronine (T4) to T3 [28].
Germain, "Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in human and rat brain and other tissues," Journal of Clinical Investigation, vol.
Type II iodothyronine deiodinase provides intracellular 3,5,3'-triiodothyronine to normal and regenerating mouse skeletal muscle.
Cloning of the mammalian type II iodothyronine deiodinase: a selenoprotein differentially expressed and regulated in human and rat brain and other tissues.