COL1A2

(redirected from type I procollagen)

COL1A2

A gene on chromosome 7q21.3 that encodes the pro-alpha2 chain of type-I collagen, the triple-helix (two-alpha1, one-alpha2 chain) form of collagen found in most connective tissue and abundant in bone, cornea, dermis and tendon.

Molecular pathology
COL1A2 mutations occur in osteogenesis imperfecta types I–IV, Ehlers-Danlos syndrome type VIIB, autosomal recessive Ehlers-Danlos syndrome (classic type), idiopathic osteoporosis and atypical Marfan syndrome.
References in periodicals archive ?
In 2000, recombinant human type I procollagen trimers was expressed in Saccharomyces cerevisiae (27).
Production of recombinant human type I procollagen homotrimer in the mammary gland of transgenic mice.
Production of recombinant human type I procollagen trimers using a four-gene expression system in the yeast Saccharomyces cerevisiae.
Matrix metalloproteinases (MMPs) induction and type I procollagen reduction in photoaging of the skin due to exposure to ultraviolet (UV) irradiation.
We observed that basal and UV-induced MMP-1 expression is dose-dependently decreased by BBR, whereas basal and UV-induced type I procollagen is increased by it in human dermal fibroblasts.
Reduced serum levels of carboxy-terminal propeptide of human type I procollagen in a family with type I-A osteogenesis imperfecta.
Immunoassay for intact amino-terminal propeptide of human type I procollagen.
Circulating C-terminal propeptide of type I procollagen is cleared mainly via the mannose receptor in liver endothelial cells.
Serum concentrations of carboxy-terminal propeptide of type I procollagen, amino-terminal propeptide of type III procollagen, cross-linked carboxy-terminal telopeptide of type I collagen, and their interrelationships in schoolchildren.
the carboxy-terminal peptide of type I procollagen (PICP), appears in the blood stream during type I collagen synthesis.
Radioimmunoassay of the carboxyterminal propeptide of human type I procollagen.