squamous alveolar cells

(redirected from type I pneumocyte)

squa·mous al·ve·o·lar cells

highly attentuated squamous cells that form the gas-permeable epithelium lining the alveoli of the lungs.
References in periodicals archive ?
(92) Accordingly, after tissue damage, as observed frequently in the distal lung after a variety of insults (inflammatory, infective, toxic, etc), proliferation and hyperplasia of type II pneumocytes take place, finalized to reconstitute an integral type I pneumocyte layer.
(10) In patients with ILD, KL-6 is strongly expressed on alveolar macrophages and the type II pneumocytes that are regenerated over the alveolar basement membrane after the death of type I pneumocytes during the first stage of fibrosing lung injury.
Virus antigen expression was seen in many type II pneumocytes, few type I pneumocytes, alveolar macrophages, bronchiolar ciliated and nonciliated epithelial cells, and rare bronchial ciliated epithelial cells.
While the new study found that the 1918 ressortant strains and H5N1 each attacked specialized respiratory cells called pneumocytes, the 1918 chimaraes showed preference for so-called type I pneumocytes, responsible for air exchange in the lungs.
Type I pneumocytes are squamous or flat cells, which are connected together to form the alveolar hexagonal shape.
The immunohistochemical reactivity observed for PCNA and various markers of LAM cells was similar to that found in previous studies,[8-11,13] The type I pneumocytes were unreactive for all these components.
Other cells lining the cystic spaces corresponded to type I pneumocytes, as shown by their larger surface areas, apical surfaces, and absence of microvilli (Figure 3, A).
Such cells were considered to be suggestive of a transition from type II to type I pneumocytes. The latter were much less frequent than type II pneumocytes and were characterized by very flat shapes and a thin cytoplasm.