Multifaceted activities of type I interferon
are revealed by a receptor antagonist.
The potential new medicine binds to subunit 1 of the type I interferon
receptor, blocking the activity of all type I interferons
, including IFN-alpha, IFN-beta, and IFN-omega.
A novel strategy was developed to analyze the expression of the whole pathway as opposed to just a handful of genes, and type I interferon
pathway was highlighted.
HCV control and prevention depends on global distribution of the virus, determination of the risk factors involved, and assessment of the accelerating factors responsible for progression of the disease 4 Interferon alpha (a) and beta (AY) are subtypes of type I interferon
"We can inoculate swine with a viral vector containing the gene coding for swine type I interferon
and then challenge them with FMD virus 1 day later and protect them," Grubman says.
Rheumatoid arthritis (RA) patients with higher baseline levels of type I interferon
proteins are more likely to respond to therapy with tumor necrosis factor (TNF) antagonists, such as Enbrel, Humira and Remicade, according to a study published in the February 2010 issue of Arthritis & Rheumatism.
IFN-alpha and -beta, which are grouped together as type I interferon
, are produced by white blood cells and a type of connective tissue cell called fibroblast.
The patent, "Compositions of Highly-Purified Natural Mixtures of Type I Interferon
Derived from Leukocytes and Methods", became effective February 26, 2002.
Interferon alpha is a "type I interferon
", as is interferon beta, which is approved for use in MS as Betaseron or Avonex.
Peripheral type I interferon
receptor correlated with oxidative stress in chronic hepatitis B virus infection.