Therefore, we evaluated the in vitro efficacy of a recombinant human type I interferon
(IFN), IFN-[beta] 1a (Serono International, Geneva, Switzerland) against three different isolates of SARS-CoV (Tor2 and Tor7 and Urbani) using yield reduction assays.
Infergen is a bioengineered type I interferon
alpha indicated for treatment of adult patients with chronic hepatitis C infections.
The patent, "Compositions of Highly-Purified Natural Mixtures of Type I Interferon
Derived from Leukocytes and Methods", became effective February 26, 2002.
Promising and possible biomarkers: type I interferon
, sVCAM-1, CD27 high plasma cells, soluble IL-2 receptor, BLyS.
The biological activities of interferon take place when alpha and beta interferons bind to Type I interferon
receptor proteins, which are present in various human cells.
The native human interferon lambda proteins are generated by the immune system in response to viral infection, and signal through a different receptor than type I interferons
, such as interferon alpha.