TWSG1

(redirected from twisted gastrulation protein homolog 1)

TWSG1

A gene on chromosome 18p11.3 that encodes a protein thought to be involved in dorsoventral axis formation, which both:
(1) Antagonises bone morphogenetic protein (BMP)-signalling by forming ternary complexes with chordin and BMPs, thereby preventing BMPs from binding to their receptors; and
(2) Acts in a pro-BMP fashion by cleaving and degrading chordin, releasing BMPs from ternary complexes.