tunicamycin

tunicamycin

1. an antibiotic which inhibits the synthesis of all N-linked glycoproteins by blocking the transfer of acetylgalactosamine from UDP-N-acetylgalactosamine to dolicholphosphate.
2. bacterial toxin produced by Clavibacter rathayi which infects galls on grass caused by the nematode Anguina funesta. Called also corynetoxin.
References in periodicals archive ?
Klebsiella 370 Sulfonamide, Trimethoprim, Quinolone, Acriflavin, Glyoxalase, Bleomycin Tetracycline, Gentamicin, Tobramycin, Amikacin, Streptomycin, Colicin, Tunicamycin, Chloramphenicol,Fosfomycin, Florfenicol, Erythromycin, kanamycin, Neomycin, Apramycin, Trimethoprim, Rifampin and Spectinomycin Acinetobacter 212 Sulfonamide, Trimethoprim, Aminoglycoside,Gentamicin, Bleomycin, Carbapenem, Amikacin, Kanamycin and Neomycin.
In this study, we cultured podocytes in vitro, induced the proteinuria model using tunicamycin (TM), and analyzed the potential effects of HQH on the biological processes of [MPC.
A novel endoplasmic reticulum stressinduced apoptosis model using tunicamycin in primary cultured neonatal rat cardiomyocytes," Molecular Medicine Reports, vol.
Presence of UDP-N-Acetylmuramyl-Hexapeptides and -Heptapeptides in enterococci and staphylococci after treatment with ramoplanin, tunicamycin, or vancomycin," Journal of Bacteriology, vol.
The results show that many of these knock out lines missing various UPR-related proteins have a phenotypic difference when compared to the wild type that is reflected by changes in size and/or leaf pigmentation after Tunicamycin exposure.
Treatment of mice with the ER stress-inducing agent tunicamycin resulted in liver injury, unfolded protein response induction, and hepatic lipid accumulation that was significantly ameliorated by dietary supplementation with taurine.
Thapsigargin (TG, 586005), tunicamycin (TUN, 654380), and brefeldin A (BFA, 203729) were purchased from EMD Chemicals Inc.
Yeast cells pretreated briefly with radicicol to induce genomic instability also adapted more efficiently to the presence of other drugs including fluconazole, tunicamycin, or benomyl, when compared to euploid cells.
Tunicamycin was used to block in vivo glycosylation of the recombinant protein, tunicamycin (Sigma, T7765) was used at final concentration of 2.
Tunicamycin resistant glycosylation of coronavirus glycoprotein: demonstration of a novel type of viral glycoprotein.
N-glycosylation and complex glycan synthesis can be inhibited by specific compounds such as tunicamycin and swainsonine [8].
Salubrinal ((2E)-3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino) thioxomethyl]amino]ethyl]-2-propenamide, Sal) selectively inhibits growth arrest and DNA damage induced gene 34- (GADD34-) phosphatase complex (GADD34 associates with protein phosphatase 1 (PP1)) and promotes in vitro dephosphorylation of the alpha subunit of eIF-2[alpha] and IRE1[alpha]/ASK1/JNK signaling pathway being protective against ERS even induced by tunicamycin Tm [170].