tunicamycin

tunicamycin

1. an antibiotic which inhibits the synthesis of all N-linked glycoproteins by blocking the transfer of acetylgalactosamine from UDP-N-acetylgalactosamine to dolicholphosphate.
2. bacterial toxin produced by Clavibacter rathayi which infects galls on grass caused by the nematode Anguina funesta. Called also corynetoxin.
References in periodicals archive ?
The results show that many of these knock out lines missing various UPR-related proteins have a phenotypic difference when compared to the wild type that is reflected by changes in size and/or leaf pigmentation after Tunicamycin exposure.
Treatment of mice with the ER stress-inducing agent tunicamycin resulted in liver injury, unfolded protein response induction, and hepatic lipid accumulation that was significantly ameliorated by dietary supplementation with taurine.
Thapsigargin (TG, 586005), tunicamycin (TUN, 654380), and brefeldin A (BFA, 203729) were purchased from EMD Chemicals Inc.
Yeast cells pretreated briefly with radicicol to induce genomic instability also adapted more efficiently to the presence of other drugs including fluconazole, tunicamycin, or benomyl, when compared to euploid cells.
Tunicamycin resistant glycosylation of coronavirus glycoprotein: demonstration of a novel type of viral glycoprotein.
Louis, MO, USA) and tunicamycin (TU), thapsigargin (TG), and brefeldin A (BFA) from Calbiochem (San Diego, CA, USA).
The HepG2 cells were subsequently treated with tunicamycin (Tm, 10 [mu]g/ml) for 16 h as positive ER stress cell control and treated with high glucose culture medium (30 mmol/1) for 5 h to induce ER stress response in vitro.