tumourigenesis


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tumourigenesis

The process of tumour development, which requires changes in cellular adhesivity to facilitate disruption of normal tissue architecture and angiogenesis to provide the growing tumour a blood supply.

tu·mor·i·gen·e·sis

(tū'mŏr-i-jen'ĕ-sis)
Production of a new growth or growths.
Synonym(s): tumourigenesis.
[tumor + G. genesis, origin]
References in periodicals archive ?
6 By binding to miRNAs of protein-coding genes to act at post-transcriptional level, miRNAs have been found to be involved in tumourigenesis and tumour aggression.
Thus, in this work was studied the effect of orally administered Maitake D-fraction in mammary tumourigenesis in BALBc mice.
This strategy allowed an assessment of the role of Stat3 in cell death in the mammary gland, and the modelling of tumourigenesis in the mammary epithelium, for example following loss of function of the Wnt pathway component Apc.
In the present review we try to hypothesize a possible rationale through which insulin-sensitizers may inhibit tumourigenesis (Figure 1).
demonstrated that miR-34a could inhibit gastric cancer tumourigenesis by targeting PDGFR and MET through the PI3K/Akt pathway,[sup][18] and Cao et al .
The classic model of colorectal tumourigenesis includes several genetic changes that are required for cancer initiation and progression.
It was pre- viously believed that tumour infiltrating immune cells play a protective role in tumourigenesis.
The commercial launch of this enhanced data will allow scientists to make further discoveries in tumourigenesis and disease progression, as well as provide a valuable validation set for internal trials, BioDiscovery noted.
Renal tumourigenesis in male rats in response to chronic dietary ochratoxin A.
Toll-like receptor (TLR) 7 and TLR8 expression on CD133+ cells in colorectal cancer points to a specific role for inflammation-induced TLRs in tumourigenesis and tumour progression.
It is noteworthy that a distinctive host response to microbiota is observed through activation of different downstream effectors in the TLR pathway; (5), (6) the implication of which in the intestinal homeostasis and tumourigenesis is still unknown.