The research project's aim is now to test a new immunotherapy in which the previously identified proteins will be used to reprogram tumour cells into cells that present tumour-specific antigens
recognized by the immune system.
According to the terms of the contract, DarwinHealth will use a combined single-cell transcriptome analysis and bioinformatics-based approach using both mouse and human cancerous and non-cancerous tissues to identify the next generation of shared 'off-the-shelf' tumour-specific antigens
. HOOKIPA will perform the validation experiments and be granted exclusive rights to the development, manufacturing and commercialisation of products arising from the collaboration.
The immune system can target tumour cells for destruction by recognizing tumour-associated or tumour-specific antigens
displayed on their surface.
London, January 23 (ANI): Harvard University researchers have shown that small plastic disks, when impregnated with tumour-specific antigens
and implanted under the skin, can coax the mammalian immune system to attack tumours.
The new products will be developed from Sorrento's G-MAB library compared with neoepitopes of tumour-specific antigens
discovered using NantWorks' pan-omics based, precision medicine approach.
The expansion will include emerging areas of research in the immune response to tumour neo-antigens, truly tumour-specific antigens
that are generated as tumours accumulate genetic mutations.
The tests, Octava Pink and Octava Blue, identify the presence or absence of cancer by assessing ratios of autoantibodies released in response to the presence of tumour-specific antigens
. The assays are intended for use with annual screening mammograms, giving additional information that allows improved evaluation of the validity of the mammography findings.