tumour necrosis factor
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tumour necrosis factorEither of two molecules—TNF-alpha or -beta—which mediate shock and tumour-related cachexia. TNF-alpha (cachexin) has sequence homology with other biological response mediators, including lymphotoxin, interferons, interleukin-l and granulocyte-macrophage-colony-stimulating factor.
TNF-alpha is a multi-purpose molecule in the immune system: it is an endogenous pyrogen, induces apoptosis and inflammation, triggers the sepsis response by upregulating IL-1 and IL-6, and it inhibits tumourigenesis and viral replication. TNF-alpha misbehaviour is linked to Alzheimer's disease, cancer, depression and inflammatory bowel disease.
Fever, headache, hypotension, cachexia, chills, fatigue, anorexia and thrombocytopaenia.
Some providers of alternative healthcare believe that TNF can be used to stimulate the immune response in patients with immune suppression caused by chemotherapy and radiotherapy.