tumour necrosis factor


Also found in: Dictionary, Thesaurus, Wikipedia.
Related to tumour necrosis factor: Cytokines, Interleukins

tumour necrosis factor

Either of two molecules—TNF-alpha or -beta—which mediate shock and tumour-related cachexia. TNF-alpha (cachexin) has sequence homology with other biological response mediators, including lymphotoxin, interferons, interleukin-l and granulocyte-macrophage-colony-stimulating factor.
 
Cell roles
TNF-alpha is a multi-purpose molecule in the immune system: it is an endogenous pyrogen, induces apoptosis and inflammation, triggers the sepsis response by upregulating IL-1 and IL-6, and it inhibits tumourigenesis and viral replication. TNF-alpha misbehaviour is linked to Alzheimer's disease, cancer, depression and inflammatory bowel disease.

Toxicity
Fever, headache, hypotension, cachexia, chills, fatigue, anorexia and thrombocytopaenia.

Alternative oncology
Some providers of alternative healthcare believe that TNF can be used to stimulate the immune response in patients with immune suppression caused by chemotherapy and radiotherapy.

tumour necrosis factor

One of two related CYTOKINES capable of killing certain cancer cells and which also have regulatory functions on the immune system. Tumour necrosis factor is implicated in various inflammatory diseases including RHEUMATOID ARTHRITIS.
References in periodicals archive ?
Genetic association studies of tumour necrosis factor alpha and beta and tumour necrosis factor receptor 1 and 2 polymorphisms across the clinical spectrum of multiple sclerosis.
Comparison of clinical and demographic features between affected pairs of Italian multiple sclerosis multiplex families; relation to tumour necrosis factor genomic polymorphisms.
Based on our data, we think miR-30d probably plays multiple roles, both in enhancing insulin production and in protecting cells from the inflammatory effects of tumour necrosis factor," the biologist added.
Interleukin-6, tumour necrosis factor and soluble tumour necrosis factor receptors in women with pre-eclampsia.
Bioactive tumour necrosis factor alpha in pre-eclamptic patients with and without the HELLP syndrome.
Tumour necrosis factor a and its promoter polymorphisms' role in the phenotypic expression of hemochromatosis.

Full browser ?