tumour necrosis factor


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Related to tumour necrosis factor: Cytokines, Interleukins

tumour necrosis factor

Either of two molecules—TNF-alpha or -beta—which mediate shock and tumour-related cachexia. TNF-alpha (cachexin) has sequence homology with other biological response mediators, including lymphotoxin, interferons, interleukin-l and granulocyte-macrophage-colony-stimulating factor.
 
Cell roles
TNF-alpha is a multi-purpose molecule in the immune system: it is an endogenous pyrogen, induces apoptosis and inflammation, triggers the sepsis response by upregulating IL-1 and IL-6, and it inhibits tumourigenesis and viral replication. TNF-alpha misbehaviour is linked to Alzheimer's disease, cancer, depression and inflammatory bowel disease.

Toxicity
Fever, headache, hypotension, cachexia, chills, fatigue, anorexia and thrombocytopaenia.

Alternative oncology
Some providers of alternative healthcare believe that TNF can be used to stimulate the immune response in patients with immune suppression caused by chemotherapy and radiotherapy.

tumour necrosis factor

One of two related CYTOKINES capable of killing certain cancer cells and which also have regulatory functions on the immune system. Tumour necrosis factor is implicated in various inflammatory diseases including RHEUMATOID ARTHRITIS.
References in periodicals archive ?
Genetic association studies of tumour necrosis factor alpha and beta and tumour necrosis factor receptor 1 and 2 polymorphisms across the clinical spectrum of multiple sclerosis.
Based on our data, we think miR-30d probably plays multiple roles, both in enhancing insulin production and in protecting cells from the inflammatory effects of tumour necrosis factor," the biologist added.
Increased levels of cytokines including tumour necrosis factor (TNF) alpha play an important role in the inflammatory process in Crohn's disease (CD).
Association between polymorphism of tumour necrosis factor alpha-308 gene promoter and asthma: a meta-analysis.
Primary biliary cirrhosis shows association with genetic polymorphism of tumour necrosis factor a promoter region.
However, some types of these molecules, such as tumour necrosis factor (TNF) family cytokines, may play a dual role.
More specifically, FDA has approved ACTEMRA for the treatment of adult patients with moderately to severely active RA who have had an inadequate response to one or more tumour necrosis factor (TNF) antagonist therapies.
Polymorphism at position -308 of the tumour necrosis factor alpha gene and rheumatoid arthritis pharmacogenetics.
Polymorphisms in or near tumour necrosis factor (TNF)-gene do not determine levels of endotoxin-induced TNF production.
Rattray, "Tumour necrosis factor alpha induces rapid reduction in AMPA receptor-mediated calcium entry in motor neurones by increasing cell surface expression of the GluR2 subunit: relevance to neurodegeneration," Journal of Neurochemistry, vol.

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