tumour marker


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Related to tumour marker: CA19-9

tumour marker

Any specific substance present in increased amounts in serum that may be used for early cancer (CA) detection. Most tumour markers are nonspecific and of little use as screening tools; they may be used to detect recurrence (e.g., CEA in patients with known colorectal and other CAs).  

Examples
Oncofoetal proteins (alpha-fetoprotein) for hepatic carcinoma; CA125 for ovarian CA; CEA for ovarian, lung, breast, pancreas, GI tract CAs; PSA for prostate CA.

tu·mor mark·er

(tū'mŏr mahr'kĕr)
A substance released into the circulation by tumor tissue; its detection in the serum indicates the presence and specific type of tumor.
Synonym(s): tumour marker.

tu·mor mark·er

(tū'mŏr mahr'kĕr)
A substance released into the circulation by tumor tissue; its detection in the serum indicates the presence and specific type of tumor.
Synonym(s): tumour marker, tumour marker.
References in periodicals archive ?
GTS is chemotherapeutic retro-conversion characterized by an increase in metastatic mass after complete eradication of a primary malignant ovarian germ cell tumour and by normalization of serum tumour markers, either during or after chemotherapy.1,2 Incidence of GTS is 12% after ovarian germ cell tumours.3,4 There are one hundred one cases of ovarian GTS from literature published between 1977 and 2015.5 Reason for occurrence of GTS is not exactly known but hypothetically there are two major inferences of GTS formation that is chemotherapy transforms malignant cells into "benign" teratomatous elements and chemotherapy can only destroy malignant cells leaving chemoresistant teratoma behind.4,6
For HE 4 tumour marker and at the cut-off point of >25 pM, sensitivity was 1, specificity 0.40, positive cut-off value 0.19, negative cut-off value 1, accuracy 0.47 and positive likelihood ratio 1.65.
In terms of clinical decision making, it is imperative that elevations of this tumour marker are interpreted in the context of other diagnostic and prognostic markers available to the mutildisciplinary team.
There were 16 [beta]-hCG tumour marker requests during the audited period, three from GPs and 13 hospital based.
The tumour marker value at the time of diagnosis may be used as a prognostic indicator for disease progression and patient survival.
By contrast, blood-borne markers are markers at a distance, which can provide information about the presence or absence of disease, but, certainly so far, provide little information about future disease behaviour (other than the somewhat facile observation that qualitatively higher levels of tumour markers are more likely to be associated with larger disease volume, and its consequent implications).
Briana Bio-Tech Inc., an Edmonton, Alberta-based biotechnology company, will soon hit the Canadian market with North America's only approved lung cancer tumour marker test.
The main aim of the study is to establish whether KRAS mutations can be assessed in urine to monitor treatment response in patients that test either positive or negative for the tumour marker CA19-9.
An important tumour marker is serum AY-hCG which not only helps in establishing diagnosis but also in assessing response to chemotherapy.

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