Tumour lysis syndrome and acute kidney injury in high-risk haematology patients in the rasburicase era.
The 26-year-old, from Llanrug, near Caernarfon, died from Acute
Tumour Lysis Syndrome (ATLS) a known complication of life-saving chemotherapy treatment after "opportunities were missed" to diagnose the condition sooner and "optimise her chances of survival".
A post-mortem into his death was not carried out but the cause of death was recorded as Spontaneous
Tumour Lysis Syndrome caused by a malignant tumour.
Tumour lysis syndrome: new therapeutic strategies and classification.
Tumour lysis syndrome was not observed in any child.
Naoi et al., "A case of metastatic testicular cancer complicated by
tumour lysis syndrome and choriocarcinoma syndrome," Japanese Journal of Clinical Oncology, vol.
Acute tubular necrosis is the most common renal AKI seen in lymphoma patients, with lysozyme-induced tubular necrosis and
tumour lysis syndrome being common etiologies (Luciano & Brewster, 2014).
Bishop, "
Tumour lysis syndrome: new therapeutic strategies and classification," British Journal of Haematology, vol.
Tholouli, "The clinical management of
tumour lysis syndrome in haematological malignancies," British Journal of Haematology, vol.
There was no clinical or biochemical evidence of
tumour lysis syndrome.
The principle of
tumour lysis syndrome, prophylaxis/treatment includes virgous hydration, adequate diuresis, control of hyperuricemia with rasburicase or allopurinol, regulation of serum electrolytes and dialysis should be the treatment options.