tumour lysis syndrome

tumour lysis syndrome

The release of cellular breakdown products that occurs when tumour cells are killed by effective anticancer treatment. There is a rise in blood potassium, uric acid and phosphates and a drop in calcium. The effect may be a severe metabolic disturbance that can cause prolonged illness and may prove fatal. Severe kidney damage may occur from urate crystal deposition.
References in periodicals archive ?
Tumour lysis syndrome and acute kidney injury in high-risk haematology patients in the rasburicase era.
The 26-year-old, from Llanrug, near Caernarfon, died from Acute Tumour Lysis Syndrome (ATLS) a known complication of life-saving chemotherapy treatment after "opportunities were missed" to diagnose the condition sooner and "optimise her chances of survival".
A post-mortem into his death was not carried out but the cause of death was recorded as Spontaneous Tumour Lysis Syndrome caused by a malignant tumour.
Tumour lysis syndrome: new therapeutic strategies and classification.
Naoi et al., "A case of metastatic testicular cancer complicated by tumour lysis syndrome and choriocarcinoma syndrome," Japanese Journal of Clinical Oncology, vol.
Acute tubular necrosis is the most common renal AKI seen in lymphoma patients, with lysozyme-induced tubular necrosis and tumour lysis syndrome being common etiologies (Luciano & Brewster, 2014).
Bishop, "Tumour lysis syndrome: new therapeutic strategies and classification," British Journal of Haematology, vol.
Tholouli, "The clinical management of tumour lysis syndrome in haematological malignancies," British Journal of Haematology, vol.
The principle of tumour lysis syndrome, prophylaxis/treatment includes virgous hydration, adequate diuresis, control of hyperuricemia with rasburicase or allopurinol, regulation of serum electrolytes and dialysis should be the treatment options.

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