SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity
Benvenisty, "The tumorigenicity
of human embryonic stem cells," Advances in Cancer Research, vol.
Effects of microRNA-29 on apoptosis, tumorigenicity
, and prognosis of hepatocellular carcinoma," Hepatology, vol.
These new tissue-, cell-, or gene therapy-based products will likely require additional testing such as immunogenicity, tumorigenicity
, and biodistribution analyses to support product safety.
The potential for tumorigenicity
makes BPyV contamination of bovine serum, biologicals seeds and other raw materials used for manufacture of veterinary and human products a cause for concern.
Adult stem cells per se display very few complications, while the major potential risk associated with pluripotent cells is tumorigenicity
Since the transferred semi-allogeneic F1 NKT cells will be eliminated in a few days, this strategy reduces the intrinsic anxiety on tumorigenicity
of iPS-derived cells in vivo.
Objective: "It is well documented that each human cancer has acquired a large number of mutations (50-500), some of which are drivers for tumorigenicity
, others of which are indolent passengers.
Activator protein 2 alpha inhibits tumorigenicity
and represses vascular endothelial growth factor transcription in prostate cancer cells.
Chronic in vitro exposure to 3'-azido-2', 3'-dideoxythymidine induces senescence and apoptosis and reduces tumorigenicity
of metastatic mouse mammary tumor cells.
Previous studies have reported that alterations in adult stem cells contributed to the enhancement of tumorigenicity
(Strong et al.
Downregulation of miR-610 promotes proliferation and tumorigenicity
and activates Wnt/[beta]-catenin signaling inhuman hepatocellular carcinoma.