In summary, loss of TIP30 expression might be associated with BUC tumorigenesis
and is an independent predictor for OS in patients with BUC.
This data suggests that CK2 and Survivin are associated with one another to promote tumorigenesis
especially in early cancer stage of both the prostate and breast cancers.
reviewed the cytokines pattern due to their involvement in the inflammatory processes that can trigger and sustain tumorigenesis
Based on in vivo data, VEGF-C-driven SOD3 expression increases the tumorigenesis
and metastasis of xenografted mammary cells .
In contrast to breaking of robustness in carcinogen-driven tumorigenesis
, viral infections, such as HPV, hepatitis B virus, and Epstein-Barr virus, induce tumorigenesis
through systematic and potentially predictable mechanisms.
This edition has been revised and updated to include recent advances and information on the tumor microenvironment, metastatic dissemination, tumor immunology, cancer stem cells, the epithelial-mesenchymal transition, multi-step tumorigenesis
, invasion and metastasis, mutation of cancer cell genomes, epigenetic contributions, microRNA involvement, and the Warburg effect, with more on traditional therapy and a new list of key techniques.
The consistency of these findings suggests that these fatty acids are involved in prostate tumorigenesis
and recommendations to increase long-chain omega-3 fatty acid intake, in particular through supplementation, should consider its potential risks," the US study said.
The mechanism identified here provides a clear explanation: A mutation in CHD7 leads to a blockage of differentiation in stem cells, which is a major cause of tumorigenesis
Recently it has become evident that genetic mutations are not the sole determinants of either tumorigenesis
or cancer heterogeneity.
The expression of ER/PR/inhibin in the ovarian-type stroma also supports a putative role for female hormones in the tumorigenesis
Without it, YAP1 moves into the cell nuclei and activates genes whose products trigger tumorigenesis
and cell proliferation.
The endpoints of these Phase I trials included data on tumorigenesis
, adverse events, immunological reactions, laboratory and ECG findings.