Administration of RORgamma agonist-treated T cells to tumor-bearing mice as an adoptive cell therapy resulted in numerous effects, including: extended persistence of cytokine-producing T cells in vivo; increased tumor-infiltrating lymphocytes
(TILs); reduced immune suppression as measured by decreased PD-1 expression in TILs; and enhanced presence of long-lasting memory immune cells in the spleen.
predict response to anthracycline-based chemotherapy in estrogen receptor-negative breast cancer.
Preclinical trials show that CM-24 enhances the cytotoxic activity of tumor-infiltrating lymphocytes
(TILs) against various CEACAM1-positive tumor cell lines.
CRC in LS patients is well recognized to be associated with several histopathologic features, including an origin in the right colon, a poorly differentiated or medullary histology with mucinous or signet ring cells, abundant tumor-infiltrating lymphocytes
, and peritumoral lymphoid follicles--the so-called Crohn-like lymphocytic reaction (12).
4) Other specific histologic details displayed by some UECs were marked nuclear pleomorphism and multinucleation, and prominent tumor-infiltrating lymphocytes
High number of intraepithelial CD8+ tumor-infiltrating lymphocytes
is associated with the absence of lymph node metastases in patients with large early-stage cervical cancer.
The presence of tumor-infiltrating lymphocytes
has been shown to significantly improve clinical outcomes in many types of cancer.
When more tumor-infiltrating lymphocytes
are present, the body is more capable of attack-ing and eliminating the tumor.
Stingl noted there is an ongoing renaissance of passive immunotherapy achieved through infusion of large numbers of autologous tumor-infiltrating lymphocytes
that recognize melanoma-associated antigens.
Experiments in mice showed these cells, known as tumor-infiltrating lymphocytes
(TILs) to be 50 to 100 times more effective at attacking tumor cells.
The cells used in this innovative cancer treatment are called TIL cells, for tumor-infiltrating lymphocytes
The study is an outgrowth of a 1989 experiment in which Rosenberg and his co-workers treated melanoma patients with genetically modified cells called tumor-infiltrating lymphocytes