tumor-infiltrating lymphocytes

tu·mor-in·fil·trat·ing lym·pho·cytes (TIL, TILS),

(lim'fō-sītz),
lymphocytes collected from the site of a tumor and exposed to IL-2 in vitro to expand the population. When these cells are reinjected into the tumor-bearing host, they will specifically kill the tumor from which they originated.
References in periodicals archive ?
The study is designed to assess whether a single cycle of ImmunoPulse IL-12 increases TNBC tumor immunogenicity by driving a pro-inflammatory cascade of events including activation of cytotoxic tumor-infiltrating lymphocytes.
NKTR-214 is the first I-O agent to both increase tumor-infiltrating lymphocytes (TILs) and increase PD-1 expression on human immune cells, which uniquely complements checkpoint inhibition and other anti-cancer mechanisms.
In addition, the presence or absence of tumor-infiltrating lymphocytes and peritumoral lymphoid aggregates was noted.
Tumor-infiltrating lymphocytes are associated with improved survival in multiple types of cancer, including endometrial.
Previous investigations indicated that tumor-infiltrating lymphocytes represent the host immune response to cancer and further suggested that CD8(+) cytotoxic T-cells have a central role in eliminating tumors and that regulatory T-cells may suppress the immune reaction.
Additionally, the company's lead product candidate is an adoptive cell therapy using tumor-infiltrating lymphocytes (TIL) for the treatment of patients with refractory metastatic melanoma, and is based on a clinical Cooperative Research and Development Agreement with the National Cancer Institute.
Vaccine trials directed against high-grade brain tumors such as glioblastoma multiforme [17] have incorporated the use of dendritic cells pulsed with tumor lysate [18, 19], antibodies to tumor antigen EGFRvIII [20], irradiated tumor injected with immunomodulators [21], and adoptive transfer of immunity of expanded tumor-infiltrating lymphocytes [22].
In melanoma, through homophilic interactions, CEACAM1 inhibits natural killer (NK) cell activity and effector functions (such as cytotoxicity and interferon gamma (IFNy) release) of tumor-infiltrating lymphocytes (TILs).
Tumor-infiltrating lymphocytes predict response to anthracycline-based chemotherapy in estrogen receptor-negative breast cancer.
Preclinical trials show that CM-24 enhances the cytotoxic activity of tumor-infiltrating lymphocytes (TILs) against various CEACAM1-positive tumor cell lines.
In addition, fresh tumor-infiltrating lymphocytes have been observed to be poorly cytotoxic against tumor targets and do not undergo normal signaling in response to T-cell receptor engagement.
High number of intraepithelial CD8+ tumor-infiltrating lymphocytes is associated with the absence of lymph node metastases in patients with large early-stage cervical cancer.

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