Two reasons can be postulated to explain the relationship between tumor-infiltrating lymphocytes
Khammari et al., "Infusion of Melan-A/Mart-1 specific tumor-infiltrating lymphocytes
enhanced relapse-free survival of melanoma patients," Cancer Immunol Immunother, vol.
Gillanders, "The presence of programmed death 1 (PD-1)-positive tumor-infiltrating lymphocytes
is associated with poor prognosis in human breast cancer," Breast Cancer Research and Treatment, vol.
Tenner et al., "Association of stromal tumor-infiltrating lymphocytes
with recurrence-free survival in the N9831 adjuvant trial in patients with early-stage HER2-positive breast cancer," JAMA Oncology, vol.
Otherwise, tumor-infiltrating lymphocytes
(TILs) produce high levels of programmed cell death protein 1 (PD-1) and interact with its specific ligand, known as programmed cell death ligand 1 (PDL-1) overexpressed by PDAC cells, resulting in T lymphocyte depletion (Figure 3) [68, 69].
Mule, "Reflections on the histopathology of tumor-infiltrating lymphocytes
in melanoma and the host immune response," Cancer Immunology Research, vol.
Schalper et al., "PD-L1 expression correlates with tumor-infiltrating lymphocytes
and response to neoadjuvant chemotherapy in breast cancer," Cancer Immunology Research, vol.
Utsumi et al., "CD8+ tumor-infiltrating lymphocytes
at primary sites as a possible prognostic factor of cutaneous angiosarcoma," International Journal of Cancer, vol.
Evaluation of Stromal Tumor-Infiltrating Lymphocytes
. Pre-therapy biopsies were retrieved from the Pathology Departments at the Sapienza University Teaching Hospital and the San Giovanni-Addolorata Hospital.
Presence of tumor-infiltrating lymphocytes
is an independent prognostic factor in type I and II endometrial cancer.
predict response to anthracycline-based chemotherapy in estrogen receptor-negative breast cancer.
Preclinical trials show that CM-24 enhances the cytotoxic activity of tumor-infiltrating lymphocytes
(TILs) against various CEACAM1-positive tumor cell lines.