tumor-infiltrating lymphocyte


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tumor-infiltrating lymphocyte

A ymphocyte found in solid tumors, e.g., lung cancers, melanomas, and renal cell carcinomas. Tumor-infiltrating lymphocytes include helper T cells and cytotoxic T cells; they participate in tumor recognition and, in some cases, tumor destruction.
See also: lymphocyte
References in periodicals archive ?
Two reasons can be postulated to explain the relationship between tumor-infiltrating lymphocytes and metastasis:
Khammari et al., "Infusion of Melan-A/Mart-1 specific tumor-infiltrating lymphocytes enhanced relapse-free survival of melanoma patients," Cancer Immunol Immunother, vol.
Gillanders, "The presence of programmed death 1 (PD-1)-positive tumor-infiltrating lymphocytes is associated with poor prognosis in human breast cancer," Breast Cancer Research and Treatment, vol.
Tenner et al., "Association of stromal tumor-infiltrating lymphocytes with recurrence-free survival in the N9831 adjuvant trial in patients with early-stage HER2-positive breast cancer," JAMA Oncology, vol.
Otherwise, tumor-infiltrating lymphocytes (TILs) produce high levels of programmed cell death protein 1 (PD-1) and interact with its specific ligand, known as programmed cell death ligand 1 (PDL-1) overexpressed by PDAC cells, resulting in T lymphocyte depletion (Figure 3) [68, 69].
Mule, "Reflections on the histopathology of tumor-infiltrating lymphocytes in melanoma and the host immune response," Cancer Immunology Research, vol.
Schalper et al., "PD-L1 expression correlates with tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy in breast cancer," Cancer Immunology Research, vol.
Utsumi et al., "CD8+ tumor-infiltrating lymphocytes at primary sites as a possible prognostic factor of cutaneous angiosarcoma," International Journal of Cancer, vol.
Evaluation of Stromal Tumor-Infiltrating Lymphocytes. Pre-therapy biopsies were retrieved from the Pathology Departments at the Sapienza University Teaching Hospital and the San Giovanni-Addolorata Hospital.
Presence of tumor-infiltrating lymphocytes is an independent prognostic factor in type I and II endometrial cancer.
Tumor-infiltrating lymphocytes predict response to anthracycline-based chemotherapy in estrogen receptor-negative breast cancer.
Preclinical trials show that CM-24 enhances the cytotoxic activity of tumor-infiltrating lymphocytes (TILs) against various CEACAM1-positive tumor cell lines.

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