tumor-induced osteomalacia

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softening of the bones, resulting from impaired mineralization, with excess accumulation of osteoid, caused by a vitamin D deficiency in adults. A similar condition in children is called rickets. The deficiency may be due to lack of exposure to ultraviolet rays, inadequate intake of vitamin D in the diet, or failure to absorb or utilize vitamin D. There is decalcification of the bones, particularly those of the spine, pelvis, and lower extremities. X-ray examination reveals transverse, fracture-like lines in the affected bones and areas of demineralization in the matrix of the bone. As the bones soften they become bent, flattened, or otherwise deformed. Treatment consists of administration of large daily doses of vitamin D and dietary measures to insure adequate calcium and phosphorus intake. adj., adj osteomala´cic.
antacid-induced osteomalacia osteomalacia in which the combination of low dietary phosphorus intake and chronic excessive consumption of aluminum hydroxide–containing antacids has led to phosphate depletion; characteristics include hypophosphatemia, nephrolithiasis, anorexia, muscle weakness, and bone loss.
anticonvulsant osteomalacia
1. osteomalacia occurring in anticonvulsant rickets of children.
hepatic osteomalacia osteomalacia as a complication of cholestatic liver disease, which may lead to severe bone pain and multiple fractures.
oncogenic osteomalacia a type seen in association with usually benign mesenchymal neoplasms. The tumors appear to produce a substance that impairs renal tubular functions and leads to hypophosphatemia. Called also tumor-induced osteomalacia.
puerperal osteomalacia a type resulting from exhaustion of skeletal stores of calcium and phosphorus by repeated pregnancies and lactation.
renal tubular osteomalacia a type resulting from acidosis and hypercalciuria when deficient renal tubular activity has caused inability to produce acid urine or ammonia.
senile osteomalacia softening of bones in old age due to vitamin D deficiency.
tumor-induced osteomalacia oncogenic osteomalacia.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


(os?te-o-mal-a'she-a) [Gr. osteon, bone, + malakia, softening]
A vitamin D deficiency in adults that results in a shortage or loss of calcium salts, causing bones to become increasingly soft, flexible, brittle, and deformed. An adult form of rickets, osteomalacia can also be traced to liver disease, cancer, or other ailments that inhibit the normal metabolism of vitamin D.osteomalacic (-mal-a'sik), adjective


Clinical findings are pains in the limbs, spine, thorax, and pelvis; fractures; anemia; and progressive weakness.


The disease is caused by any of the many vitamin D disorders or by deranged phosphorus metabolism.


In patients with vitamin D–deficient diets, ergocalciferol and calcium are given as nutritional supplements.

oncogenic osteomalacia

A rare disorder in which low serum phosphorus levels and excessive wasting of phosphorus by the kidneys accompany weakening and softening of bone. The disease is found in patients with cancer and is caused by excessive circulating levels of fibroblast growth factor.
Synonym: tumor-induced osteomalacia.

tumor-induced osteomalacia

Oncogenic osteomalacia.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Shakur et al., "En bloc spondylectomy for treatment of tumor-induced osteomalacia: case report," Journal of Neurosurgery: Spine, vol.
Minisola, "Octreotide for tumor-induced osteomalacia," New England Journal of Medicine, vol.
* Patients with tumor-induced osteomalacia are characterized biochemically by hypophosphatemia, hyperphosphaturia, inappropriately low or normal 1,25-dihydroxyvitamin D concentration, and increased alkaline phosphatase concentration.
* Besides routine laboratory tests such as serum phosphate, alkaline phosphatase, PTH, and vitamin D and urine phosphate, serum FGF23 should be ordered when tumor-induced osteomalacia is suspected.
Improving diagnosis of tumor-induced osteomalacia with Gallium-68 DOTATATE PET/CT.
Venous sampling for fibroblast growth factor-23 confirms preoperative diagnosis of tumor-induced osteomalacia. J Clin Endocrinol Metab 2004;89: 3979-82.
Tumor-induced osteomalacia (TIO) [2] is a rare condition, well described in the literature.

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