tumor-associated antigen


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Related to tumor-associated antigen: Cancer Antigens

tu·mor-·as·so·ci·at·ed an·ti·gen

antigens that are highly correlated with certain tumor cells. They are not usually found, or are found to a lesser extent, on normal cells.

tumor-associated antigen

Immunology, oncology A molecule–eg, CA 15.3, 19-9, CA-125, that may be associated with specific tumors–eg, lymphomas, carcinomas, sarcomas, melanomas; TAAs may elicit cellular and/or humoral immune responses against the tumor, but rarely defend the host against the tumor
Tumor-associated antigen types
Class 1 Highly specific for a particular tumor; they are present in one or only a few individuals and not found in normal cells, eg tumor-specific transplantation antigen
Class 2 Present in a number of related tumors from different Pts
Class 3 Present on normal and malignant cells, but are expressed in ↑ amounts in malignant cells  
Note: Class 2 antigens have the  greatest potential for clinically useful assays, as they are present in many tumors and are rarely observed in normal subjects
References in periodicals archive ?
Baba et al., "Strong CD[8.sup.+] T-cell responses against tumor-associated antigens prolong the recurrence-free interval after tumor treatment in patients with hepatocellular carcinoma," Journal of Gastroenterology, vol.
Fischer, "The tumor-associated antigen PRAME is universally expressed in high-stage neuroblastoma and associated with poor outcome," Clinical Cancer Research, vol.
Regarding the targets of immunotherapy, there are different types of tumor antigens, including tumor-associated antigens (TAAs), cancer germline antigens (CGAs), virus-associated antigens, and tumor-specific antigens (TSAs) (Table 1).
Gehin et al., "Improvement of protein immobilization for the elaboration of tumor-associated antigen microarrays: application to the sensitive and specific detection of tumor markers from breast cancer sera," Biosensors and Bioelectronics, vol.
CARs can directly bind to tumor-associated antigens, carbohydrates or glycolipids.
Salmonella enterica as Delivery System of Tumor-Associated Antigens or Tumor-Specific Antigens for Cancer Therapy.
Tumor-associated antigens represent another potential type of immunization strategy.
Vaccines have been designed to induce immune responses against tumor-specific antigens or tumor-associated antigens, with the aim of inhibiting the progression of cancers expressing either antigen.
As a normal cell undergoes tumorigenesis, it expresses aberrant protein antigens, known as tumor-associated antigens (TAAs).
"PVS-RIPO may stimulate an immune response that can recognize tumor-associated antigens and that can selectively kill tumor cells," said Dr.
During the elimination phase, the cancer immunoediting is directed towards antitumor immunity, and it mainly depends on the expression of tumor-associated antigens (TAAs) presented by major histocompatibility complex (MHC) class I molecules.
Therapeutic vaccines currently in development use antigens that are derived from proteins, carbohydrates, glycoproteins, glycopeptides, or gangliosides, as well as attenuated tumor-associated antigens that are employed in autologous or allogeneic formulations.

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