tumor-associated antigen


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Related to tumor-associated antigen: Cancer Antigens

tu·mor-·as·so·ci·at·ed an·ti·gen

antigens that are highly correlated with certain tumor cells. They are not usually found, or are found to a lesser extent, on normal cells.

tumor-associated antigen

Immunology, oncology A molecule–eg, CA 15.3, 19-9, CA-125, that may be associated with specific tumors–eg, lymphomas, carcinomas, sarcomas, melanomas; TAAs may elicit cellular and/or humoral immune responses against the tumor, but rarely defend the host against the tumor
Tumor-associated antigen types
Class 1 Highly specific for a particular tumor; they are present in one or only a few individuals and not found in normal cells, eg tumor-specific transplantation antigen
Class 2 Present in a number of related tumors from different Pts
Class 3 Present on normal and malignant cells, but are expressed in ↑ amounts in malignant cells  
Note: Class 2 antigens have the  greatest potential for clinically useful assays, as they are present in many tumors and are rarely observed in normal subjects
References in periodicals archive ?
Under the terms of the multi-year agreement, PCT will provide current good manufacturing practice (cGMP) services for the manufacture of clinical supplies of ICT-107, a dendritic cell-based immunotherapy targeting six tumor-associated antigens.
ICT-107 is a dendritic cell based vaccine targeting multiple tumor-associated antigens and cancer stem cells in development as a potential treatment for glioblastoma.
ImmunoCellular has concluded a phase II trial of its lead product candidate, ICT-107, a dendritic cell-based vaccine targeting multiple tumor-associated antigens for glioblastoma.
The Company has commenced a Phase II trial of its lead product candidate, ICT-107, a dendritic cell-based vaccine targeting multiple tumor-associated antigens for glioblastoma.

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