Human tumor viruses
carry oncogenes which when incorporated into host cell are usually responsible for transformation of target cells by expression of oncoproteins and alteration in cellular machinery3.
For now, many DNA tumor viruses
are known; they are grouped in four families, namely, SV40 and polyomavirus, papilloma viruses (HPV), adenoviruses, and herpesviruses.
Finally, we discuss the biological evidence or lack thereof that avian tumor viruses
are involved in the etiology of human cancer and multiple sclerosis (MS).
Cancer transcriptomes often have rearranged genomes and harbor transcripts that are not encoded in a reference genome, like those derived from tumor viruses
Beginning at the "dawn of molecular biology" in the 1930s-40s, selected vignettes give the background behind the discovery of DNA tumor viruses
, advances in understanding cell cycle regulation, repair and replication mechanisms, and apoptosis, and unexpected insights from such places as Klinefelter's syndrome and Drosophila mutations.
Steinberg did a fellowship studying mammalian tumor viruses
at the State University of New York, Stony Brook.
Immunodeficiency (whether congenital, iatrogenic, or caused by infection) increases the risk of some types of cancer, especially malignancies etiologically linked to DNA tumor viruses
, such as herpesviruses and polyomavirus.
Recalling a meeting in 1973 where scientists considered the potential risks in working with tumor viruses
, he says there was already a feeling that "some things might be dangerous.