specific genes such as ND5 were evaluated for tumor promoter
and promoter effects.
It has been shown that TET1 functions as a tumor suppressor and tumor promoter
in a cancer type-dependent manner.
In addition, controversies still exist whether PGC-1[alpha] acts as a tumor promoter
or a tumor suppressor in cancer.
Kapila, "SIRT3 and cancer: tumor promoter
or suppressor?," Biochimica et Biophysica Acta, vol.
However, whether the role of ACS5 is being a tumor suppressor or a tumor promoter
remains controversial, and its underlying mechanisms have not been clarified.
All eight substances also exhibited moderate inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) in Raji cells as a primary screening test for tumor promoter
Notch signaling is one of the most studied pathways involved in tumorigenesis, and increasing evidence indicates that the Notch pathway can function as a tumor promoter
or suppressor, depending on the cell type and context (7).
As already mentioned, TGF-[beta] can act either as a tumor suppressor or as a tumor promoter
. Suppression of tumor cell growth by TGF-[beta] depends on its ability to upregulate the cyclin kinase inhibitors which inhibit cell proliferation.
Treatment with carcinogen (7,12-dimethylbenz[[alpha]]anthracene, DMBA) followed by tumor promoter
(12-O-tetradecanoylphorbol-13-acetate, TPA) is known to cause tumor formation .
decreased lysophosphatidic acid (a tumor promoter
that accelerates plaque build-up in arteries in animal models) and less atherosclerotic plaque.
This particular experiment suggests that vemurafenib is acting as a tumor promoter
in cell lines with this pre-existing HRAS Q61L mutation via the paradoxical activation of the MAPK pathway in non-melanomatous cells with wild type BRAF, as evidenced by increased ERK phosphorylation and increased expression of ERK-related genes.