tumor promoter

tumor promoter

Cocarcinogen A substance, often lipid-soluble, that has no intrinsic carcinogenic potential, but which, when applied repeatedly, amplifies cancer-inducing effects of other (initiator) substances. See Antipromoter. Cf Tumor initiator.
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Tan, however, cited the World Health Organization's 2016 report on the Electronic Nicotine Delivery Systems and Electronic Non-Nicotine Delivery Systems which described nicotine as a tumor promoter.
All eight substances also exhibited moderate inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) in Raji cells as a primary screening test for tumor promoter inhibitors.
We have now identified mutations in CDK6 that convert it from a tumor promoter into a tumor suppressor.
COX-2 was first reported in 1991 by a group of scientists and they described a viral oncogene or a tumor promoter had induced the COX-2 (Xie et al.
decreased lysophosphatidic acid (a tumor promoter that accelerates plaque build-up in arteries in animal models) and less atherosclerotic plaque.
This particular experiment suggests that vemurafenib is acting as a tumor promoter in cell lines with this pre-existing HRAS Q61L mutation via the paradoxical activation of the MAPK pathway in non-melanomatous cells with wild type BRAF, as evidenced by increased ERK phosphorylation and increased expression of ERK-related genes.
The researchers applied 12-O-tetradecanolylphorbol-13-acetate (TPA), a tumor promoter, to the ears of mice to induce inflammation (edema), which was accompanied by increases in a series of biomarkers.
okadaic acid induce the secretion of TNF-[alpha] from various cells, then the TNF-[alpha] acts as an endogenous tumor promoter (Komori et al.
For example, the gene CMye is a known tumor promoter.
Monsanto continues to claim that BGH milk is no different from other milk, despite documentation that it contains substantially higher levels of a potent cancer tumor promoter called IGF-1.
Most miscarriages do not result in an increased risk because of an insufficiency of estrogen, a known tumor promoter.
The negative control group of each cell type was not irradiated and the positive control was irradiated and also treated with tumor promoter PMA (phorbol 12-meristate 13-acetate; 20 [micro]l/ml of medium).

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