tumor promoter

tumor promoter

Cocarcinogen A substance, often lipid-soluble, that has no intrinsic carcinogenic potential, but which, when applied repeatedly, amplifies cancer-inducing effects of other (initiator) substances. See Antipromoter. Cf Tumor initiator.
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decreased lysophosphatidic acid (a tumor promoter that accelerates plaque build-up in arteries in animal models) and less atherosclerotic plaque.
Eating genetically engineered tomatoes reduces plaque build-up in mice
The researchers applied 12-O-tetradecanolylphorbol-13-acetate (TPA), a tumor promoter, to the ears of mice to induce inflammation (edema), which was accompanied by increases in a series of biomarkers.
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For example, a tumor promoter may be hypomethylated (therefore no longer turned off), leading to promotion of a cancer.
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okadaic acid induce the secretion of TNF-[alpha] from various cells, then the TNF-[alpha] acts as an endogenous tumor promoter (Komori et al.
Bioactivity guided isolation of anticancer constituents from leaves of Alnus sieboldiana (Betulaceae)
The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase.
An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis
For example, the gene CMye is a known tumor promoter.
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Most miscarriages do not result in an increased risk because of an insufficiency of estrogen, a known tumor promoter.
ABORTION-BREAST CANCER CONNECTION BEGINNING TO HAVE ITS DAY IN COURT
The negative control group of each cell type was not irradiated and the positive control was irradiated and also treated with tumor promoter PMA (phorbol 12-meristate 13-acetate; 20 [micro]l/ml of medium).
p53 as a Diagnostic Tool for the Detection of Cancer
The MMP stromelysin-1 (MMP3) exhibits several activities that would make it a particularly good tumor promoter.
MMP1 and MMP3 polymorphisms in promoter regions and cancer
12] The results of carcinogenicity assays have been equivocal, but the dye does appear to act as a tumor promoter.
A cluster of acoustic neuromas in fish hatchery workers
The prototypic member of this family, TGF-beta, plays a dual role in carcinogenesis, acting as a tumor suppressor in early stages and as tumor promoter in late stages of tumor progression.
Research and Markets: Competitor Analysis: TGF-R Agonists and Antagonists - A Competitor Evaluation in the Field of Transforming Growth Factor Receptor
And now, a mice study has confirmed that obesity does indeed act as a "bona fide tumor promoter.
How obesity ups cancer risk

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