tumor promoter

tumor promoter

Cocarcinogen A substance, often lipid-soluble, that has no intrinsic carcinogenic potential, but which, when applied repeatedly, amplifies cancer-inducing effects of other (initiator) substances. See Antipromoter. Cf Tumor initiator.
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decreased lysophosphatidic acid (a tumor promoter that accelerates plaque build-up in arteries in animal models) and less atherosclerotic plaque.
The researchers applied 12-O-tetradecanolylphorbol-13-acetate (TPA), a tumor promoter, to the ears of mice to induce inflammation (edema), which was accompanied by increases in a series of biomarkers.
For example, a tumor promoter may be hypomethylated (therefore no longer turned off), leading to promotion of a cancer.
okadaic acid induce the secretion of TNF-[alpha] from various cells, then the TNF-[alpha] acts as an endogenous tumor promoter (Komori et al.
The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase.
For example, the gene CMye is a known tumor promoter.
Most miscarriages do not result in an increased risk because of an insufficiency of estrogen, a known tumor promoter.
The negative control group of each cell type was not irradiated and the positive control was irradiated and also treated with tumor promoter PMA (phorbol 12-meristate 13-acetate; 20 [micro]l/ml of medium).
The MMP stromelysin-1 (MMP3) exhibits several activities that would make it a particularly good tumor promoter.
12] The results of carcinogenicity assays have been equivocal, but the dye does appear to act as a tumor promoter.
The prototypic member of this family, TGF-beta, plays a dual role in carcinogenesis, acting as a tumor suppressor in early stages and as tumor promoter in late stages of tumor progression.
And now, a mice study has confirmed that obesity does indeed act as a "bona fide tumor promoter.

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