tumor necrosis factor receptor-associated periodic syndrome


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tumor necrosis factor receptor–associated periodic syndrome

,

TRAPS

A rare, dominantly inherited autoinflammatory disorder marked by bouts of abdominal pain, fever, myalgia and arthralgia, pleurisy, and conjunctivitis. It is caused by a mutation in a cell receptor for tumor necrosis factor. See: tumor necrosis factor
Medical Dictionary, © 2009 Farlex and Partners
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Modeling of tumor necrosis factor receptor superfamily 1A mutants associated with tumor necrosis factor receptor-associated periodic syndrome indicates misfolding consistent with abnormal function.
Brucato et al., "Clues to detect tumor necrosis factor receptor-associated periodic syndrome (TRAPS) among patients with idiopathic recurrent acute pericarditis: results of a multicentre study," Clinical Research in Cardiology, vol.
Only one case of solid organ transplant was found in the literature where etanercept was used for the treatment of tumor necrosis factor receptor-associated periodic syndrome (TRAPS) in a renal transplant patient with improvement of condition and no complications (6).
The target genes were those causing hemoglobin disorders, glucose-ophosphate dehydrogenase deficiency, the receptor 1 for tumor necrosis factor-[alpha] (TNFRSFIA), responsible for tumor necrosis factor receptor-associated periodic syndrome (TRAPS; MIM 142680), and the MEFV gene, which is involved in familial Mediterranean fever (FMF; MIM 249100).

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