BOSTON -- Doxycycline reduced headache frequency and intensity in a small, open-label investigation of patients with treatment-resistant new daily persistent headache who had elevated cerebrospinal fluid levels of tumor necrosis
Although the efficacy of tumor necrosis
factor (TNF) antagonists for the treatment of rheumatoid arthritis (RA) has been established in randomized controlled trials (RCTs), safety concerns have emerged, particularly with regard to risk of infection, malignancy, and cardiovascular (CV) outcomes.
Researchers evaluated the anti-inflammatory properties of HMRIignan, (from Norway Spruce, Picea abies) and its metabolite enterolactone on the production of tumor necrosis
factor (TNF)-alpha in a human cell line (THP-I).
BACKGROUND: Polymorphisms in the proinflammatory cytokine genes tumor necrosis
factor-[alpha] (TNF) and lymphotoxin-[alpha] (LTA, also called TNF-[beta]) have been associated with asthma and atopy in some studies.
Since we detected a clear increase of IL-6, IL-10, and tumor necrosis
factor [alpha] (TNF[alpha]) during the acute phase of infection (IL-6 133.0 pg/dL, IL-10 218.0 U/mL, and TNF[alpha] 29.7 pg/mL), we assume that lymphoplasmacytoid cells in bone marrow and peripheral blood of our patient and his production of oligoclonal [gamma]-globulins were due to PUUV-induced cytokine release.
(Rockville, MD) and University of Michigan (Ann Arbor, MI) has patented Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis
factor (TNF) receptor family.
CR014 has shown in vitro that it can prevent vascular leak caused by clinically relevant inflammatory stimulus such as Tumor necrosis
factor, as well as agents involved in thrombosis (thrombin) and allergies (histamine).
When testing for proinflammatory cytokines such as tumor necrosis
factor-[alpha] (TNF-[alpha]) and interleukin-6 (IL-6), it is essential that all reagents and supplies are free from contamination with endotoxin and other bacteria-derived components with cell-stimulatory activity.
As the body lurches into a self-defense mode, it mass-produces inflammatory proteins, such as tumor necrosis
factor alpha (TNF-alpha) and high-mobility group box 1 (HMGB1).
(19) Tumor necrosis
factor alpha and interleukin 1-beta, which are produced by leukocytes, induce ephrin-A1 in melanomas as host inflammatory responses to tumor.
Studies have shown that anthralin inhibits interleukin 6, interleukin 8, and tumor necrosis
Techniclone Corporation (NASDAQ:TCLN), Tustin, Calif., has completed patient enrollment in the radiation dosimetry (imaging) portion of the current Phase I Tumor Necrosis
Therapy (TNT) protocol for malignant glioma (brain cancer).