tumor marker


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marker

 [mahr´ker]
something that identifies or that is used to identify; see also determinant.
cell-surface marker an antigenic determinant found on the surface of a specific type of cell.
tumor marker a biochemical substance indicative of presence of a tumor; ideally, it should be specific, sensitive, and proportional to tumor load. Called also biomarker.

tu·mor mark·er

a substance, released into the circulation by tumor tissue, the detection of which in the serum indicates the presence of tumor.

tumor marker

a substance in the body that may be associated with the presence of a cancer.

tumor marker

Biomarker Oncology Any substance present in ↑ amounts in serum that may be used for early CA detection; most TMs are nonspecific and little used to screen for CA; they may be used to detect recurrence–eg, CEA in Pts with known colorectal and other CAs Examples Oncofetal proteins–α-fetoprotein, CA-125–ovarian CA, CA-15-3–breast CA, CEA–ovarian, lung, breast, pancreas, GI tract CAs, PSA–prostate CA

tu·mor mark·er

(tū'mŏr mahr'kĕr)
A substance released into the circulation by tumor tissue; its detection in the serum indicates the presence and specific type of tumor.
Synonym(s): tumour marker.

tu·mor mark·er

(tū'mŏr mahr'kĕr)
A substance released into the circulation by tumor tissue; its detection in the serum indicates the presence and specific type of tumor.
Synonym(s): tumour marker, tumour marker.

Patient discussion about tumor marker

Q. what is a safe tumor marker number range?

A. depends on the marker...most of the markers are materials that found normally in our body. and there are a number of markers and their levels differentiate. what marker do you mean?

Q. My wife(53) has elevated CEA and CA19.9 levels - near 150, without any concomitant reason/observation? Comment

A. Hi Bobby3,

The most important question is why were these tests done?
An elevated level may result from many causes, some of them are simple and some are more problematic. IMHO the best thing would be consulting her doctor to consider the need to check-up her alimentary system.
You can read more here (http://www.ascocancerfoundation.org/patient/ASCO+Resources/Patient+Guides/ASCO+Patient+Guide:+Tumor+Markers+for+Gastrointestinal+Cancers) and here (http://www.cancer.gov/cancertopics/factsheet/Detection/tumor-markers)

More discussions about tumor marker
References in periodicals archive ?
The potential limitations of our study are, one tumor marker was studied as CA 15-3 can also be used for detecting breast cancer alongwith CEA and sensitivity is even more with their combined assessment as evaluated in various international studies5,10.
Markers' sensitivity--Mean probability of determining an elevated tumor marker level--over the "cut-off value"--in a tumor-bearing patient)
The new MONITOR guidelines are welcome because they pinpoint the importance of validating the use of serum tumor markers.
The objective measurement of remission and progression in metastatic breast cancer by use of serum tumor markers.
Basically a tumor marker is a cloned protein, antibody or antigen that is coded to target and bind with proteins, enzymes or proteins having a specific gene, mutation, or property within a cell.
Assuming the assay is reliable, the method is standardized, the interpretation of the assay understood and clearly reported, and the clinical study has an LOE of I, when should a tumor marker be used to make clinical decisions?
Objective: To compare the serum level of tissue polypeptide antigen (TPA) and interleukin-6 (IL-6) in women with breast cancer at various stages of the disease and to consider the usefulness of these tumor markers in evaluating the response to chemotherapy.
Frequently, the conclusions in published tumor marker studies are based solely on statistical significance.
This study aimed to investigate the relationship between the preoperative tumor marker levels and different clinical aspects of gastric cancer.

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