tumor development

tumor development

A multistep process that occurs over yrs in which a tissue accumulates genetic hits that eventually translate into a neoplasm with metastatic potential. See One-hit, two-hit model.
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Metformin reduced lung tumor development primarily through an insulin-dependent mechanism by decreasing circulating levels of insulin-like growth factor-I (IGF).
IL-8 has also been shown to be involved in aggressive aspects of tumor development, such as metastasis and cancer stem cell renewal.
CFS instability is associated with tumor development and pathogenic copy number variations.
The scientists discovered that TRPV1, once activated by the EGFR, initiates a direct negative feedback on the EGFR, dampening the latter to reduce the risk of unwanted growth and intestinal tumor development.
Fat cells near tumors secrete a variety of extracellular factors, some of which boost tumor development and progression, report researchers at the University of Texas Southwestern Medical Center, Dallas.
Researchers say this is useful as methylation in promoter sequences can indicate tumor development in most major types of cancer and may be a better biomarker than many genetic markers.
Researchers concluded that anthocyanin-rich bilberry extract may induce beneficial pharmacodynamic changes to counter tumor development.
The new study clarifies the active region of telomerase and provides the first view of the telomerase molecule's critical protein component at the atomic level, showing the enzyme's configuration and how it works--a process critical to tumor development and the aging process.
These results are consistent with animal studies demonstrating that constant light, dim light at night, or simulated chronic jet lag can substantially increase tumor development.
Scientists supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) at the National Institutes of Health have created two mouse strains that will permit researchers to trace, in a live animal, the activity of an enzyme believed to play a crucial role both in the normal immune response as well as autoimmunity and B cell tumor development.
After inoculation 12 of 18 animals developed solid tumors while tumor development was seen in only 5 of 18 CR treated animals.
His claims that a battery of ten markers, listed below, have a high degree of specificity and sensitivity toward various indicators of tumor development.