tumor development

tumor development

A multistep process that occurs over yrs in which a tissue accumulates genetic hits that eventually translate into a neoplasm with metastatic potential. See One-hit, two-hit model.
References in periodicals archive ?
Those new nerves, in turn, promote tumor development and make more catecholamines, perpetuating the cycle.
Because there is a chance of secondary tumor development, the decision to surgically excise the lesion or closely follow for transformation is controversial.
In turn, ACTH stimulates the adrenal gland to produce Cortisol, which then acts on the pituitary gland to halt the growth of ACTH-producing cells, effectively suppressing any tumor development.
When cancer develops, the generated cells are not uniform in their biological properties and contribute differently to tumor development.
Our results show for the first time that walnut consumption may reduce colon tumor development,' said Daniel W.
In a third trial, the authors investigated whether amygdalin prevents tumor development using the same mouse strain as before, but before tumors had developed.
The current study investigated the impact of dietary sugar on mammary gland tumor development in multiple mouse models, along with mechanisms that may be involved," said co-author Lorenzo Cohen, Ph.
First, ROS are known to regulate each and every step of tumor development including transformation, survival, proliferation, invasion, metastasis, and angiogenesis.
Metformin reduced lung tumor development primarily through an insulin-dependent mechanism by decreasing circulating levels of insulin-like growth factor-I (IGF).
In order to aid anti-cancer drug discovery, I present a multiscale model that integrates tumor growth and angiogenesis into a simulation of tumor development for drug assessment.
Fat cells near tumors secrete a variety of extracellular factors, some of which boost tumor development and progression, report researchers at the University of Texas Southwestern Medical Center, Dallas.