ADCC is an immune-mediated cell-killing process inherent to macrophages and NK cells that is activated through the engagement of mAbs bound to cell-surface tumor antigens
Developing additional TCR product candidates retrovirally engineered to target tumor antigens
, including for the treatment of colorectal and lung cancers.
Memopi contains ten optimized epitopes, derived from these five tumor antigens
, which generate strong specific T cytotoxic responses that lead to the body's immune system preventing the growth of tumor cells expressing these tumor antigens
Although their presentations vary, syndromes occur when tumor antigens
exhibit cross-reactivity to similar antigens expressed by these systems.
have been identified for some cancers.
These nine articles describe some of the work being done to differentiate markers and use their presence to detect and treat a range of cancers, addressing the characterization of breast cancer subtypes in a large retrospective study, intraocular lymphoma markers, polymorphisms in genes associated with certain T-cell lymphomas, tumor antigens
that are markers of minimal residual disease in acute myeloid leukemia, thyroid tumor markers, activity and expression of dipeptidyl peptidase IV and cathepsin H in human cutaneous melanoma compared to other common cancers, melanoma inhibitory activity as a serological marker in metastic melanoma, and the promise (or myth) of the tumor necrosis factor alpha receptors p55 and p75 in ovarian cancer detection.
The discovery of a central role for HMGB1 and TLR2 in overcoming immune ignorance to brain tumor antigens
provides a new therapeutic approach in the fight against brain tumors.
Galenica's GPI-0100 series are safe semi-synthetic derivatives from certain natural saponins which have the capability of stimulating Th 1 immunity with production of antigen-specific cytotoxic T cells (CTL) that will seek out and destroy cells carrying abnormal markers such as viral or tumor antigens
In a twist on that strategy, Raposo and her colleagues loaded laboratory-grown dendritic cells with potential tumor antigens
The dramatic effect of HAART on KS and PCNSL incidence is postulated to result from partial reconstitution of immunity and enhanced responses to viral and other tumor antigens
SELECT Therapeutics' ACTIVATE system incorporates tumor antigens
into a proprietary molecular form which specifically binds to dendritic cells, allowing uptake and processing to a form which can stimulate the immune system to attack cancer cells.
SAGE is an integral part of Genzyme Molecular Oncology's therapeutic discovery efforts with particular emphasis on the identification of novel tumor antigens
and antiangiogenic factors.