tuftsin


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tuftsin

 [tuft´sin]
a tetrapeptide cleaved from IgG that stimulates phagocytosis by neutrophils. It is produced primarily in the spleen; hereditary tuftsin deficiency and tuftsin deficiency following splenectomy result in increased susceptibility to certain infections.

tuft·sin

(tŭf'sin),
A tetrapeptide derived from the Fc region of an immunoglobulin. Tuftsin enhances macrophage functions.
[Tufts University + -in]

tuftsin

/tuft·sin/ (tuft´sin) a tetrapeptide cleaved from IgG that stimulates phagocytosis by neutrophils.

tuftsin

a basic tetrapeptide produced in the spleen that stimulates phagocytosis in polymorphonuclear leukocytes and in macrophages.
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References in periodicals archive ?
Targeting of efavirenz loaded tuftsin conjugated poly(propyleneimine) dendrimers to HIV infected macrophages in vitro.
The company is using its MIDAS technology to design tuftsin analogues possessing high potency and stability.
Quilty said that the new phase I studies "will involve the refinement of MIDAS-based RGD and tuftsin analogues and their extensive testing in animal models.
He added that the company will employ the study results to support applications for phase II SBIR grants, which would involve continued preclinical testing and development, followed by initial human trials both of the RGD and tuftsin products.
Quilty, the imaging technology currently being developed by the company is based on tuftsin, a tetrapeptide that is a natural component of the human immune system.
An isotope-labeled tuftsin molecule binds to infection/inflammation-fighting white blood cells, which enables the physician to pinpoint with nuclear diagnostic equipment where the infection/inflammation site is situated and its characteristics," Quilty explained.

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