tuftsin


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tuftsin

 [tuft´sin]
a tetrapeptide cleaved from IgG that stimulates phagocytosis by neutrophils. It is produced primarily in the spleen; hereditary tuftsin deficiency and tuftsin deficiency following splenectomy result in increased susceptibility to certain infections.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

tuft·sin

(tŭf'sin),
A tetrapeptide derived from the Fc region of an immunoglobulin. Tuftsin enhances macrophage functions.
[Tufts University + -in]
Farlex Partner Medical Dictionary © Farlex 2012
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References in periodicals archive ?
Shou et al., "Tuftsin prevents the negative immunoregulation of [neuropilin-1.sup.high][CD4.sup.+] [CD25.sup.+] regulatory T cells and improves survival rate in septic mice," Oncotarget, vol.
Blednov et al., "The anxiolytic action of an analog of the endogenous peptide tuftsin on inbred mice with different phenotypes of the emotional stress reaction," Zhurnal Vysshei Nervnoi Deiatelnosti Imeni I P Pavlova, vol.
Tsirka, "Tuftsin fragment 1-3 is beneficial when delivered after the induction of intracerebral hemorrhage," Stroke, vol.
Tsirka, "Modulation of microglial/macrophage activation by macrophage inhibitory factor (TKP) or tuftsin (TKPR) attenuates the disease course of experimental autoimmune encephalomyelitis," BMC Immunology, vol.
Tsirka, "Tuftsin promotes an anti-inflammatory switch and attenuates symptoms in experimental autoimmune encephalomyelitis," PLoS ONE, vol.
Targeting of efavirenz loaded tuftsin conjugated poly(propyleneimine) dendrimers to HIV infected macrophages in vitro.
Similar approaches were employed using tuftsin, a naturally occurring tetrapeptide known to induce phagocytosis, or ghrelin, which acts as an anti-inflammatory hormone [88, 89].
Cultures treated with tuftsin fragment1-3, a microglial/macrophage inhibitory factor (MIF), had less cytokine secretion.
Tsirka, "Modulation of microglial/ macrophage activation by macrophage inhibitory factor (TKP) or tuftsin (TKPR) attenuates the disease course of experimental autoimmune encephalomyelitis," BMC Immunology, vol.