The pathological alterations were graded as follows: 0: no visible lesions, 2: mild dilation of tubules, tubulointerstitial
inflammatory infiltration, and lesion area < 20%; 4: dilation of tubules, tubulointerstitial
inflammatory infiltration, and lesion area < 40%; and 6: severe dilation of tubules, massive tubulointerstitial
inflammatory infiltration, and lesion area > 40% .
7-11) It may cause various clinical presentations based on involved organ such as sclerosing pancreatitis, sclerosing cholangitis, prostatitis, tubulointerstitial
nephritis, interstitial pneumonia, and enlargement of salivary glands.
TGP treatment significantly decreased the number of macrophages in the glomeruli and tubulointerstitial
Histological changes were evaluated by quantitative measurement of tubulointerstitial
injury, which was assessed by counting the number of necrotic and apoptotic cells, loss of tubular brush border, tubular dilatation, cast formation, and neutrophil infiltration.
Out of the 40 patients with diffuse renal parenchymal disease, 14 had been diagnosed with glomerulonephritis and 26 with tubulointerstitial
High uric acid also aids in the development of other diseases like the albuminuria microvascular disease glomerulosclerosis and tubulointerstitial
fibrosis (Nakagawa et al.
Consistent with a reduced GFR on clinical presentation, collapsing FSGS cases have more tubulointerstitial
injury than those with the tip variant [15,18,20,29].
injury, cast nephropathy, is the most common cause of severe AKI in patients with MM ([congruent to] 90% of cases).
The renal origin of miR-21 can by postulated not only because of the lack of correlation between plasma and urine concentrations (37) but also because miR-21 has been shown to be produced in the renal tubulointerstitial
area in mice (38).
2,5-7) Systemic diseases that may be associated with uveitis in children include juvenile idiopathic arthritis (JIA), Behcet's disease, sarcoidosis, tubulointerstitial
nephritis, and Kawasaki disease.
Extrapancreatic manifestations are observed in 19% to 50% of cases and include multifocal biliary strictures, renal lesions from tubulointerstitial
nephritis, retroperitoneal fibrosis, Sjogren's syndrome, and inflammatory bowel disease (Figures 11 and 12).
The typical lesion is tubulointerstitial
nephritis, characterized by interstitial edema and dense focal infiltration of predominantly mononuclear cells.