Renal neoplasm with eosinophilic cells should also enter the differential diagnosis, which includes entities such as oncocytoma, chromophobe RCC, tubulocystic carcinoma
, unclassified RCC with rhabdoid differentiation, and MiT family translocation RCC.
Tubulocystic carcinoma of the kidney: Clinicopathological analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma.
Renal tubulocystic carcinoma is closely related to papillary renal cell carcinoma: Implications for pathologic classification.
Tubulocystic carcinoma, mucinous tubular and spindle cell carcinoma, and other recently described rare renal tumors.
Comparison of gene expression profiles in tubulocystic carcinoma and collecting duct carcinoma of the kidney.
Is tubulocystic carcinoma with dedifferentiation a form of HLRCC/fumarate hydratase-deficient RCC [abstract 1035]?
Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma.
33) However, subsequently it has been demonstrated that tubulocystic carcinoma and collecting duct carcinoma are distinct entities molecularly.
Microscopically, tubulocystic carcinoma is composed of tightly packed tubules and cysts separated by thin fibrovascular septa (Figure 2, C).
of the kidney is a well-circumscribed tumor with pure tubular and cystic growth patterns, cysts and tubules lined by a single layer of atypical cells with abundant eosinophilic cytoplasm and a variable hobnail appearance, and stromal desmoplasia (Figure 9).
dagger]) Tubulocystic carcinoma
is a distinct low-grade variant of renal cell carcinoma that was not listed in the 2004 WHO classification.
63) It is now recognized that AMACR can show positivity in tumors from many different organs and in several different types of renal tumors, including most MiTF/TFE family translocation carcinomas, tubulocystic carcinomas
, some collecting duct carcinomas, most mucinous tubular and spindle cell carcinomas, most acquired cystic disease-associated renal cell carcinomas, and some high-grade urothelial carcinomas of the renal pelvis.