tubulin-tyrosine ligase

tu·bu·lin-·ty·ro·sine li·gase

an enzyme that covalently links a tyrosine to the C-terminal glutamyl residue of tubulin, coupled with the hydrolysis of ATP to ADP and orthophosphate; this is a unique posttranslational modification that may have a significant role in cytoskeletal traffic, design, and stability.


A gene on chromosome 22q13.1 that encodes a catalytic subunit of the neuronal tubulin polyglutamylase complex which modifies alpha- and beta-tubulin.
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