TUBB3

(redirected from tubulin beta-3 chain)

TUBB3

A gene on chromosome 16q24.3 that encodes a beta tubulin, which is a major constituent of microtubules. TUBB3 plays a key role in proper axon guidance and maintenance.

Molecular pathology
Defects of TUBB3 cause congenital fibrosis of extraocular muscles type 3A, and cortical dysplasia complex with other brain malformations.
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References in periodicals archive ?
Further western blot analysis on 14 donors confirms that tubulin beta-3 chain could be a biomarker of skin aging.
Membranes were blocked with TBS-Tween 0.5% containing 5% nonfat milk and incubated with the tubulin beta-3 chain antibody (MA1-118; Thermoscientific) at 1/1000 dilution in TBS-Tween 0.5% containing 5% nonfat milk overnight at 4[degrees]C.
Western blot results of tubulin beta-3 chain were illustrated by box plots, and receiver operating characteristic curve (ROC curve) was created by using GraphPad Prism version 7.00 for Windows (GraphPad Software, La Jolla California USA, http://www.graphpad.com).
Western Blot Analysis of Tubulin Beta-3 Chain, a Promising Candidate Protein Biomarker of Aging.
In this work, tubulin beta-3 chain expression is upregulated with aging in our proteomic experiment and also in western blot analyses on samples from several donors.
58 proteins were dysregulated with aging, and from this, tubulin beta-3 chain was also observed dysregulated in western blot analysis of keratinocyte extracts isolated from multiple donors.
Indeed, emerging diagnostic tools now require a combination of multiple biomarkers to achieve a better accuracy, and we propose that tubulin beta-3 chain could be one of these.