tubulin


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Related to tubulin: alpha tubulin

tubulin

 [too´bu-lin]
the constituent protein of microtubules; thought to be involved in phagocyte motility.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

tu·bu·lin

(tū'byū-lin),
A protein subunit of microtubules; it is a dimer composed of two globular polypeptides, α-tubulin and β-tubulin.
See also: dynein.
Farlex Partner Medical Dictionary © Farlex 2012

tubulin

(to͞o′byə-lĭn, tyo͞o′-)
n.
A globular protein that is the basic structural constituent of microtubules.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

tu·bu·lin

(tū'byū-lin)
A protein subunit of microtubules; it is a dimer composed of two globular polypeptides, α-tubulin and β-tubulin.
See also: dynein
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

tubulin

A contractile protein that forms microtubules. These form the spindle fibres in MITOSIS that draw chromosomes apart is the course of cell division.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

tubulin

a globular protein molecule, similar to ACTIN, that is the building block of microtubules within the cytoplasm of cells.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
Thus, as previously we reported in one of our patients with Naxos disease, the enhanced automaticity of ectopic foci and/or reentry circuit around the scar tissue was abolished by cytoskeletal disruption mechanism, induced by tubulin destabilization with low-dose colchicines.6 Additionally interesting, colchicine also upregulates other proteins involved in the autophagic clearance of misfolded proteins such as the master regulator Transcription Factor EB (TFEB).
Differential expression of tyrosinated tubulin in Spisula solidissima polar bodies.
Potent inhibition of tubulin polymerization and proliferation of paclitaxel-resistant human ovarian cancer cells by albendazole.
Primary antibodies used in immunoblot experiments were as follows: rabbit anti-SOX2 (1:10000, Genetex), rabbit anti-[beta]III tubulin (1:3000, Epitomics), rabbit anti-Ascl (1:1000, Abcam), rabbit anti-Notch (1:1000, Abcam), mouse anti-p27 (1:6000, BD Biosciences), rabbit anti-a-tubulin (1: 150000, Abcam), and rabbit anti-actin (1:15000, Epitomics).
Notably, we observed a significant increase in detyrosination of tubulin content (Glu-tubulin), but not of the a (Figure 3(a))- and [beta] (Figure 3(b))-tubulin subunits, in the diaphragm of mdx/IL6 mice compared to mdx littermates (Figure 3(c)).
further endorse the significance of tubulin acetylation to sperm motility, as the acetylation levels differed between normozoospermic and asthenozoospermic individuals [13].
The use of tubulin-targeting agents is limited by the development of resistance to anticancer drugs, which is induced by tubulin isotype mutation and the alteration of microtubule dynamics (Cheung et al., 2010; Natarajan and Senapati, 2012).
It possesses cytotoxic anti-tubulin activity by binding to the colchicine site of tubulin causing microtubule depolymerization.
Heavier proteins in our SDS-PAGE assays that coimmunoprecipitate with each of the RPeL27 and RPeL43 proteins (Figure 2(b)) were later identified as POTE Ankyrin Family Member E- tubulin alpha 1A (POTEE-TUBA1A) and beta actin-beta actin-like 2 (ACTB-ACTBL2) complexes via the MALDI-TOF analysis (Table 2).
Furthermore the current studies show that VTN can promote cell adhesion and contribute to the maintenance of Tubulin structures.