tubulin


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Related to tubulin: alpha tubulin

tubulin

 [too´bu-lin]
the constituent protein of microtubules; thought to be involved in phagocyte motility.

tu·bu·lin

(tū'byū-lin),
A protein subunit of microtubules; it is a dimer composed of two globular polypeptides, α-tubulin and β-tubulin.
See also: dynein.

tubulin

/tu·bu·lin/ (too´bu-lin) the constituent protein of microtubules.

tubulin

(to͞o′byə-lĭn, tyo͞o′-)
n.
A globular protein that is the basic structural constituent of microtubules.

tu·bu·lin

(tū'byū-lin)
A protein subunit of microtubules; it is a dimer composed of two globular polypeptides, α-tubulin and β-tubulin.
See also: dynein

tubulin

A contractile protein that forms microtubules. These form the spindle fibres in MITOSIS that draw chromosomes apart is the course of cell division.

tubulin

a globular protein molecule, similar to ACTIN, that is the building block of microtubules within the cytoplasm of cells.

tubulin

the constituent protein of microtubules of cells which provide a skeleton for maintaining cell shape and is thought to be involved in cell motility.

α-tubulin
with β-tubulins contributes to the heterodimer tubulin, the building blocks of the electron microscopically visible cell components, the microtubules.
β-tubulin
one of the monomeric globular proteins which associate to form the dimer, α,β-tubulin, the basis of microfilaments.
References in periodicals archive ?
Tubulin genes are primarily divided into 2 families, [alpha] and [beta] (Cleveland & Sullivan 1985).
D'Ambra continued, "The tubulin inhibitor program is an asset developed from our past R&D investments.
In the present study, adducts with the structural proteins actin and tubulin were isolated from both rat and monkey nasal epithelial incubations.
Use of the tubulin bound paclitaxel conformation for structure-based rational drug design.
4 indicate that there has been extensive and continuous duplication of tubulin genes throughout the evolution of organisms.
Experimental data by Sackett (1995) revealed the form of microtubules not as smooth cylinders, since extending from each tubulin are tiny 'hairy' projections of 4-5 nm in length, referred to as tubulin tails.
Immunostaining confirmed that stathmin binds to tubulin and showed for the first time that stathmin binds to Hsp70.
beta]2 sequence identity exerts unusual control over axoneme morphogenesis, in the sense that small alterations in [beta]2 tubulin sequence result in discrete defects in axoneme formation.
The class III [Beta]-tubulin isotype differs from the other tubulin isotypes with respect to its amino acid sequence[49] and posttranslational modifications, which include phosphorylation.
GTx-230: An orally available tubulin antagonist discovered by GTx researchers, GTx-230 has the potential to treat cancer and cancer refractory to taxane and vinca alkaloid therapy.
The novel ADC MI130004 consists of a new marine-derived tubulin inhibitor (PM050489) that is covalently bound to the HER2 antibody trastuzumab via a non-hydrolysable linker.
The pre-tubulin activity causes hyperproliferating cells to undergo apoptosis due to a disruption of the tubulin dynamics needed for these cells to pass through mitosis.